K2CO3-assisted one-pot sequential synthesis of 2-trifluoromethyl-6-difluoromethylpyridine-3,5-dicarboxylates under solvent-free conditions

Li Shen; Song Cao; Jingjing Wu; Hui Li; Jian Zhang; Mingxi Wu; Xuhong Qian

doi:10.1016/j.tetlet.2010.07.041

K₂CO₃-assisted one-pot sequential synthesis of 2-trifluoromethyl-6-difluoromethylpyridine-3,5-dicarboxylates under solvent-free conditions

Li Shen
, Song Cao^*
, Jingjing Wu
, Hui Li
, Jian Zhang
, Mingxi Wu
, Xuhong Qian

^*Corresponding author for this work

East China University of Science and Technology

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

A novel synthesis of 2-trifluoromethyl-6-difluoromethylpyridine-3,5- dicarboxylates by three-component reaction of ethyl trifluoroacetoacetate, aldehydes, and ammonium acetate in the presence of K₂CO₃ under solvent-free conditions via sequential Hantzsch reaction/dehydration/ dehydrofluorination in a one-pot process was described.

Original language	English
Pages (from-to)	4866-4869
Number of pages	4
Journal	Tetrahedron Letters
Volume	51
Issue number	37
DOIs	https://doi.org/10.1016/j.tetlet.2010.07.041
State	Published - 15 Sep 2010
Externally published	Yes

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title = "K2CO3-assisted one-pot sequential synthesis of 2-trifluoromethyl-6-difluoromethylpyridine-3,5-dicarboxylates under solvent-free conditions",

abstract = "A novel synthesis of 2-trifluoromethyl-6-difluoromethylpyridine-3,5- dicarboxylates by three-component reaction of ethyl trifluoroacetoacetate, aldehydes, and ammonium acetate in the presence of K2CO3 under solvent-free conditions via sequential Hantzsch reaction/dehydration/ dehydrofluorination in a one-pot process was described.",

author = "Li Shen and Song Cao and Jingjing Wu and Hui Li and Jian Zhang and Mingxi Wu and Xuhong Qian",

year = "2010",

month = sep,

day = "15",

doi = "10.1016/j.tetlet.2010.07.041",

language = "英语",

volume = "51",

pages = "4866--4869",

journal = "Tetrahedron Letters",

issn = "0040-4039",

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number = "37",

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TY - JOUR

T1 - K2CO3-assisted one-pot sequential synthesis of 2-trifluoromethyl-6-difluoromethylpyridine-3,5-dicarboxylates under solvent-free conditions

AU - Shen, Li

AU - Cao, Song

AU - Wu, Jingjing

AU - Li, Hui

AU - Zhang, Jian

AU - Wu, Mingxi

AU - Qian, Xuhong

PY - 2010/9/15

Y1 - 2010/9/15

N2 - A novel synthesis of 2-trifluoromethyl-6-difluoromethylpyridine-3,5- dicarboxylates by three-component reaction of ethyl trifluoroacetoacetate, aldehydes, and ammonium acetate in the presence of K2CO3 under solvent-free conditions via sequential Hantzsch reaction/dehydration/ dehydrofluorination in a one-pot process was described.

AB - A novel synthesis of 2-trifluoromethyl-6-difluoromethylpyridine-3,5- dicarboxylates by three-component reaction of ethyl trifluoroacetoacetate, aldehydes, and ammonium acetate in the presence of K2CO3 under solvent-free conditions via sequential Hantzsch reaction/dehydration/ dehydrofluorination in a one-pot process was described.

UR - https://www.scopus.com/pages/publications/77955848392

U2 - 10.1016/j.tetlet.2010.07.041

DO - 10.1016/j.tetlet.2010.07.041

M3 - 文章

AN - SCOPUS:77955848392

SN - 0040-4039

VL - 51

SP - 4866

EP - 4869

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 37

ER -

K₂CO₃-assisted one-pot sequential synthesis of 2-trifluoromethyl-6-difluoromethylpyridine-3,5-dicarboxylates under solvent-free conditions

Abstract

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