Jatropholane-type diterpenes from Euphorbia sikkimensis

Da Song Yang; You Li Zhang; Wei Bing Peng; Li Yan Wang; Zi Lei Li; Xue Wang; Ke Chun Liu; Yong Ping Yang; Hong Lin Li; Xiao Li Li

doi:10.1021/np300799n

Jatropholane-type diterpenes from Euphorbia sikkimensis

Da Song Yang, You Li Zhang, Wei Bing Peng, Li Yan Wang, Zi Lei Li, Xue Wang, Ke Chun Liu, Yong Ping Yang, Hong Lin Li, Xiao Li Li

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Four new jatropholane-type diterpenes (1-4), named sikkimenoids A-D, were isolated from the aerial parts of Euphorbia sikkimensis. The structural elucidations of 1-4 were accomplished by extensive NMR analyses, and their absolute configurations were established by ECD calculations. Compound 2 exhibited weak antiangiogenic activity with an IC₅₀ value of 43.0 μM when evaluated using a zebrafish model.

Original language	English
Pages (from-to)	265-269
Number of pages	5
Journal	Journal of Natural Products
Volume	76
Issue number	2
DOIs	https://doi.org/10.1021/np300799n
State	Published - 22 Feb 2013
Externally published	Yes

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10.1021/np300799n

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title = "Jatropholane-type diterpenes from Euphorbia sikkimensis",

abstract = "Four new jatropholane-type diterpenes (1-4), named sikkimenoids A-D, were isolated from the aerial parts of Euphorbia sikkimensis. The structural elucidations of 1-4 were accomplished by extensive NMR analyses, and their absolute configurations were established by ECD calculations. Compound 2 exhibited weak antiangiogenic activity with an IC50 value of 43.0 μM when evaluated using a zebrafish model.",

author = "Yang, \{Da Song\} and Zhang, \{You Li\} and Peng, \{Wei Bing\} and Wang, \{Li Yan\} and Li, \{Zi Lei\} and Xue Wang and Liu, \{Ke Chun\} and Yang, \{Yong Ping\} and Li, \{Hong Lin\} and Li, \{Xiao Li\}",

year = "2013",

month = feb,

day = "22",

doi = "10.1021/np300799n",

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T1 - Jatropholane-type diterpenes from Euphorbia sikkimensis

AU - Yang, Da Song

AU - Zhang, You Li

AU - Peng, Wei Bing

AU - Wang, Li Yan

AU - Li, Zi Lei

AU - Wang, Xue

AU - Liu, Ke Chun

AU - Yang, Yong Ping

AU - Li, Hong Lin

AU - Li, Xiao Li

PY - 2013/2/22

Y1 - 2013/2/22

N2 - Four new jatropholane-type diterpenes (1-4), named sikkimenoids A-D, were isolated from the aerial parts of Euphorbia sikkimensis. The structural elucidations of 1-4 were accomplished by extensive NMR analyses, and their absolute configurations were established by ECD calculations. Compound 2 exhibited weak antiangiogenic activity with an IC50 value of 43.0 μM when evaluated using a zebrafish model.

AB - Four new jatropholane-type diterpenes (1-4), named sikkimenoids A-D, were isolated from the aerial parts of Euphorbia sikkimensis. The structural elucidations of 1-4 were accomplished by extensive NMR analyses, and their absolute configurations were established by ECD calculations. Compound 2 exhibited weak antiangiogenic activity with an IC50 value of 43.0 μM when evaluated using a zebrafish model.

UR - https://www.scopus.com/pages/publications/84876715553

U2 - 10.1021/np300799n

DO - 10.1021/np300799n

M3 - 文章

C2 - 23327832

AN - SCOPUS:84876715553

SN - 0163-3864

VL - 76

SP - 265

EP - 269

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 2

ER -

Jatropholane-type diterpenes from Euphorbia sikkimensis

Abstract

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