Isoquino[4,5-bc]acridines: Design, synthesis and evaluation of DNA binding, anti-tumor and DNA photo-damaging ability

Peng Yang; Qing Yang; Xuhong Qian; Lianpeng Tong; Xiaolian Li

doi:10.1016/j.jphotobiol.2006.03.005

Isoquino[4,5-bc]acridines: Design, synthesis and evaluation of DNA binding, anti-tumor and DNA photo-damaging ability

Peng Yang
, Qing Yang
, Xuhong Qian^*
, Lianpeng Tong
, Xiaolian Li

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Several novel isoquino[4,5-bc]acridine derivatives have been designed and synthesized. Their DNA-binding, anti-tumor and DNA-photo-damaging properties were investigated. A4 exhibited the highest anti-tumor activities against both A 549 (human lung cancer cell) and P388 (murine leukemia cells). All these compounds were found to be more cytotoxic against P388 than against A549. Under 365-nm light irradiation, A3 damaged plasmid DNA pBR322 at <2 μM and cleaved DNA from form I to 100% form II by 50 μM. The mechanism studies revealed that A3 damaged DNA by electron transfer mechanism and singlet oxygen species.

Original language	English
Pages (from-to)	221-226
Number of pages	6
Journal	Journal of Photochemistry and Photobiology B: Biology
Volume	84
Issue number	3
DOIs	https://doi.org/10.1016/j.jphotobiol.2006.03.005
State	Published - 1 Sep 2006
Externally published	Yes

Keywords

Acridine
Anti-tumor activity
DNA binding
DNA photo-cleavage

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jphotobiol.2006.03.005

Cite this

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title = "Isoquino[4,5-bc]acridines: Design, synthesis and evaluation of DNA binding, anti-tumor and DNA photo-damaging ability",

abstract = "Several novel isoquino[4,5-bc]acridine derivatives have been designed and synthesized. Their DNA-binding, anti-tumor and DNA-photo-damaging properties were investigated. A4 exhibited the highest anti-tumor activities against both A 549 (human lung cancer cell) and P388 (murine leukemia cells). All these compounds were found to be more cytotoxic against P388 than against A549. Under 365-nm light irradiation, A3 damaged plasmid DNA pBR322 at <2 μM and cleaved DNA from form I to 100\% form II by 50 μM. The mechanism studies revealed that A3 damaged DNA by electron transfer mechanism and singlet oxygen species.",

keywords = "Acridine, Anti-tumor activity, DNA binding, DNA photo-cleavage",

author = "Peng Yang and Qing Yang and Xuhong Qian and Lianpeng Tong and Xiaolian Li",

year = "2006",

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doi = "10.1016/j.jphotobiol.2006.03.005",

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volume = "84",

pages = "221--226",

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T1 - Isoquino[4,5-bc]acridines

T2 - Design, synthesis and evaluation of DNA binding, anti-tumor and DNA photo-damaging ability

AU - Yang, Peng

AU - Yang, Qing

AU - Qian, Xuhong

AU - Tong, Lianpeng

AU - Li, Xiaolian

PY - 2006/9/1

Y1 - 2006/9/1

N2 - Several novel isoquino[4,5-bc]acridine derivatives have been designed and synthesized. Their DNA-binding, anti-tumor and DNA-photo-damaging properties were investigated. A4 exhibited the highest anti-tumor activities against both A 549 (human lung cancer cell) and P388 (murine leukemia cells). All these compounds were found to be more cytotoxic against P388 than against A549. Under 365-nm light irradiation, A3 damaged plasmid DNA pBR322 at <2 μM and cleaved DNA from form I to 100% form II by 50 μM. The mechanism studies revealed that A3 damaged DNA by electron transfer mechanism and singlet oxygen species.

AB - Several novel isoquino[4,5-bc]acridine derivatives have been designed and synthesized. Their DNA-binding, anti-tumor and DNA-photo-damaging properties were investigated. A4 exhibited the highest anti-tumor activities against both A 549 (human lung cancer cell) and P388 (murine leukemia cells). All these compounds were found to be more cytotoxic against P388 than against A549. Under 365-nm light irradiation, A3 damaged plasmid DNA pBR322 at <2 μM and cleaved DNA from form I to 100% form II by 50 μM. The mechanism studies revealed that A3 damaged DNA by electron transfer mechanism and singlet oxygen species.

KW - Acridine

KW - Anti-tumor activity

KW - DNA binding

KW - DNA photo-cleavage

UR - https://www.scopus.com/pages/publications/33746907877

U2 - 10.1016/j.jphotobiol.2006.03.005

DO - 10.1016/j.jphotobiol.2006.03.005

M3 - 文章

C2 - 16714120

AN - SCOPUS:33746907877

SN - 1011-1344

VL - 84

SP - 221

EP - 226

JO - Journal of Photochemistry and Photobiology B: Biology

JF - Journal of Photochemistry and Photobiology B: Biology

IS - 3

ER -

Isoquino[4,5-bc]acridines: Design, synthesis and evaluation of DNA binding, anti-tumor and DNA photo-damaging ability

Abstract

Keywords

UN SDGs

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