Iron porphyrin-catalyzed three-component reaction of ethyl diazoacetate with aliphatic amines and β,γ-unsaturated α-keto esters

Chaoqun Ma; Dong Xing; Changwei Zhai; Jiuwei Che; Shunying Liu; Jue Wang; Wenhao Hu

doi:10.1021/ol403011r

Iron porphyrin-catalyzed three-component reaction of ethyl diazoacetate with aliphatic amines and β,γ-unsaturated α-keto esters

Chaoqun Ma
, Dong Xing^*
, Changwei Zhai
, Jiuwei Che
, Shunying Liu
, Jue Wang
, Wenhao Hu

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

East China Normal University

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

An iron porphyrin-catalyzed three-component reaction of ethyl diazoacetate with aliphatic amines and β,γ-unsaturated α-keto esters is reported. The use of iron porphyrin catalyst allows aliphatic amines to be used as the substrate without encountering catalyst poisoning issue and a series of β-hydroxy-α-amino esters are produced in high yields with excellent regioselectivities.

Original language	English
Pages (from-to)	6140-6143
Number of pages	4
Journal	Organic Letters
Volume	15
Issue number	24
DOIs	https://doi.org/10.1021/ol403011r
State	Published - 20 Dec 2013

Access to Document

10.1021/ol403011r

Cite this

@article{19a258f9035b4ac3b3f17b7321328181,

title = "Iron porphyrin-catalyzed three-component reaction of ethyl diazoacetate with aliphatic amines and β,γ-unsaturated α-keto esters",

abstract = "An iron porphyrin-catalyzed three-component reaction of ethyl diazoacetate with aliphatic amines and β,γ-unsaturated α-keto esters is reported. The use of iron porphyrin catalyst allows aliphatic amines to be used as the substrate without encountering catalyst poisoning issue and a series of β-hydroxy-α-amino esters are produced in high yields with excellent regioselectivities.",

author = "Chaoqun Ma and Dong Xing and Changwei Zhai and Jiuwei Che and Shunying Liu and Jue Wang and Wenhao Hu",

year = "2013",

month = dec,

day = "20",

doi = "10.1021/ol403011r",

language = "英语",

volume = "15",

pages = "6140--6143",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "24",

}

TY - JOUR

T1 - Iron porphyrin-catalyzed three-component reaction of ethyl diazoacetate with aliphatic amines and β,γ-unsaturated α-keto esters

AU - Ma, Chaoqun

AU - Xing, Dong

AU - Zhai, Changwei

AU - Che, Jiuwei

AU - Liu, Shunying

AU - Wang, Jue

AU - Hu, Wenhao

PY - 2013/12/20

Y1 - 2013/12/20

N2 - An iron porphyrin-catalyzed three-component reaction of ethyl diazoacetate with aliphatic amines and β,γ-unsaturated α-keto esters is reported. The use of iron porphyrin catalyst allows aliphatic amines to be used as the substrate without encountering catalyst poisoning issue and a series of β-hydroxy-α-amino esters are produced in high yields with excellent regioselectivities.

AB - An iron porphyrin-catalyzed three-component reaction of ethyl diazoacetate with aliphatic amines and β,γ-unsaturated α-keto esters is reported. The use of iron porphyrin catalyst allows aliphatic amines to be used as the substrate without encountering catalyst poisoning issue and a series of β-hydroxy-α-amino esters are produced in high yields with excellent regioselectivities.

UR - https://www.scopus.com/pages/publications/84890905309

U2 - 10.1021/ol403011r

DO - 10.1021/ol403011r

M3 - 文章

AN - SCOPUS:84890905309

SN - 1523-7060

VL - 15

SP - 6140

EP - 6143

JO - Organic Letters

JF - Organic Letters

IS - 24

ER -

Iron porphyrin-catalyzed three-component reaction of ethyl diazoacetate with aliphatic amines and β,γ-unsaturated α-keto esters

Abstract

Access to Document

Other files and links

Fingerprint

Cite this