Iridium-Catalyzed Enantioselective α-C(sp3)-H Borylation of Azacycles

Lili Chen; Yuhuan Yang; Luhua Liu; Qian Gao; Senmiao Xu

doi:10.1021/jacs.0c06756

Iridium-Catalyzed Enantioselective α-C(sp³)-H Borylation of Azacycles

Lili Chen
, Yuhuan Yang
, Luhua Liu
, Qian Gao
, Senmiao Xu^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

85 Scopus citations

Abstract

We herein report an iridium-catalyzed enantioselective α-C(sp3)-H borylation of a wide range of azacycles. The combination of an iridium precursor and a chiral bidentate boryl ligand has been shown to effectively differentiate enantiotropic methylene C-H bonds from a single carbon center, affording a variety of synthetically useful azacycles from readily available starting materials with good to excellent enantioselectivities.

Original language	English
Pages (from-to)	12062-12068
Number of pages	7
Journal	Journal of the American Chemical Society
Volume	142
Issue number	28
DOIs	https://doi.org/10.1021/jacs.0c06756
State	Published - 15 Jul 2020
Externally published	Yes

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title = "Iridium-Catalyzed Enantioselective α-C(sp3)-H Borylation of Azacycles",

abstract = "We herein report an iridium-catalyzed enantioselective α-C(sp3)-H borylation of a wide range of azacycles. The combination of an iridium precursor and a chiral bidentate boryl ligand has been shown to effectively differentiate enantiotropic methylene C-H bonds from a single carbon center, affording a variety of synthetically useful azacycles from readily available starting materials with good to excellent enantioselectivities.",

author = "Lili Chen and Yuhuan Yang and Luhua Liu and Qian Gao and Senmiao Xu",

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T1 - Iridium-Catalyzed Enantioselective α-C(sp3)-H Borylation of Azacycles

AU - Chen, Lili

AU - Yang, Yuhuan

AU - Liu, Luhua

AU - Gao, Qian

AU - Xu, Senmiao

PY - 2020/7/15

Y1 - 2020/7/15

N2 - We herein report an iridium-catalyzed enantioselective α-C(sp3)-H borylation of a wide range of azacycles. The combination of an iridium precursor and a chiral bidentate boryl ligand has been shown to effectively differentiate enantiotropic methylene C-H bonds from a single carbon center, affording a variety of synthetically useful azacycles from readily available starting materials with good to excellent enantioselectivities.

AB - We herein report an iridium-catalyzed enantioselective α-C(sp3)-H borylation of a wide range of azacycles. The combination of an iridium precursor and a chiral bidentate boryl ligand has been shown to effectively differentiate enantiotropic methylene C-H bonds from a single carbon center, affording a variety of synthetically useful azacycles from readily available starting materials with good to excellent enantioselectivities.

UR - https://www.scopus.com/pages/publications/85088179301

U2 - 10.1021/jacs.0c06756

DO - 10.1021/jacs.0c06756

M3 - 文章

C2 - 32597651

AN - SCOPUS:85088179301

SN - 0002-7863

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JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 28

ER -

Iridium-Catalyzed Enantioselective α-C(sp³)-H Borylation of Azacycles

Abstract

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