Iridium-Catalyzed γ-Selective Hydroboration of γ-Substituted Allylic Amides

Hongliang Zhao; Qian Gao; Yajuan Zhang; Panke Zhang; Senmiao Xu

doi:10.1021/acs.orglett.0c00977

Iridium-Catalyzed γ-Selective Hydroboration of γ-Substituted Allylic Amides

Hongliang Zhao
, Qian Gao
, Yajuan Zhang
, Panke Zhang^*
, Senmiao Xu

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Reported here for the first time is the Ir-catalyzed γ-selective hydroboration of γ-substituted allylic amides under mild reaction conditions. A variety of functional groups could be compatible with reaction conditions, affording γ-branched amides in good yields with ≤97% γ-selectivity. We have also demonstrated that the obtained borylated products could be used in a series of C-O, C-F, C-Br, and C-C bond-forming reactions.

Original language	English
Pages (from-to)	2861-2866
Number of pages	6
Journal	Organic Letters
Volume	22
Issue number	7
DOIs	https://doi.org/10.1021/acs.orglett.0c00977
State	Published - 3 Apr 2020
Externally published	Yes

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title = "Iridium-Catalyzed γ-Selective Hydroboration of γ-Substituted Allylic Amides",

abstract = "Reported here for the first time is the Ir-catalyzed γ-selective hydroboration of γ-substituted allylic amides under mild reaction conditions. A variety of functional groups could be compatible with reaction conditions, affording γ-branched amides in good yields with ≤97\% γ-selectivity. We have also demonstrated that the obtained borylated products could be used in a series of C-O, C-F, C-Br, and C-C bond-forming reactions.",

author = "Hongliang Zhao and Qian Gao and Yajuan Zhang and Panke Zhang and Senmiao Xu",

note = "Publisher Copyright: {\textcopyright} 2020 American Chemical Society.",

year = "2020",

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doi = "10.1021/acs.orglett.0c00977",

language = "英语",

volume = "22",

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journal = "Organic Letters",

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T1 - Iridium-Catalyzed γ-Selective Hydroboration of γ-Substituted Allylic Amides

AU - Zhao, Hongliang

AU - Gao, Qian

AU - Zhang, Yajuan

AU - Zhang, Panke

AU - Xu, Senmiao

PY - 2020/4/3

Y1 - 2020/4/3

N2 - Reported here for the first time is the Ir-catalyzed γ-selective hydroboration of γ-substituted allylic amides under mild reaction conditions. A variety of functional groups could be compatible with reaction conditions, affording γ-branched amides in good yields with ≤97% γ-selectivity. We have also demonstrated that the obtained borylated products could be used in a series of C-O, C-F, C-Br, and C-C bond-forming reactions.

AB - Reported here for the first time is the Ir-catalyzed γ-selective hydroboration of γ-substituted allylic amides under mild reaction conditions. A variety of functional groups could be compatible with reaction conditions, affording γ-branched amides in good yields with ≤97% γ-selectivity. We have also demonstrated that the obtained borylated products could be used in a series of C-O, C-F, C-Br, and C-C bond-forming reactions.

UR - https://www.scopus.com/pages/publications/85082510152

U2 - 10.1021/acs.orglett.0c00977

DO - 10.1021/acs.orglett.0c00977

M3 - 文章

C2 - 32202433

AN - SCOPUS:85082510152

SN - 1523-7060

VL - 22

SP - 2861

EP - 2866

JO - Organic Letters

JF - Organic Letters

IS - 7

ER -

Iridium-Catalyzed γ-Selective Hydroboration of γ-Substituted Allylic Amides

Abstract

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