Intracellular pH-activated PEG-b-PDPA wormlike micelles for hydrophobic drug delivery

Haijun Yu; Zhiai Xu; Dangge Wang; Xianzhi Chen; Zhiwen Zhang; Qi Yin; Yaping Li

doi:10.1039/c3py00849e

Intracellular pH-activated PEG-b-PDPA wormlike micelles for hydrophobic drug delivery

Haijun Yu
, Zhiai Xu
, Dangge Wang
, Xianzhi Chen
, Zhiwen Zhang
, Qi Yin
, Yaping Li^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

CAS - Shanghai Institute of Materia Medica

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

Wormlike micelles with intracellular pH-activating properties were developed. The micelles remained in a "silent" state at physiological pH conditions (i.e. pH 7.4), but were activated in the acidic microenvironment of endocytic vesicles. The wormlike micelles could be employed as nanovectors for the intracellular delivery of hydrophobic drugs for cancer therapy.

Original language	English
Pages (from-to)	5052-5055
Number of pages	4
Journal	Polymer Chemistry
Volume	4
Issue number	19
DOIs	https://doi.org/10.1039/c3py00849e
State	Published - 7 Oct 2013

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10.1039/c3py00849e

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title = "Intracellular pH-activated PEG-b-PDPA wormlike micelles for hydrophobic drug delivery",

abstract = "Wormlike micelles with intracellular pH-activating properties were developed. The micelles remained in a {"}silent{"} state at physiological pH conditions (i.e. pH 7.4), but were activated in the acidic microenvironment of endocytic vesicles. The wormlike micelles could be employed as nanovectors for the intracellular delivery of hydrophobic drugs for cancer therapy.",

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T1 - Intracellular pH-activated PEG-b-PDPA wormlike micelles for hydrophobic drug delivery

AU - Yu, Haijun

AU - Xu, Zhiai

AU - Wang, Dangge

AU - Chen, Xianzhi

AU - Zhang, Zhiwen

AU - Yin, Qi

AU - Li, Yaping

PY - 2013/10/7

Y1 - 2013/10/7

N2 - Wormlike micelles with intracellular pH-activating properties were developed. The micelles remained in a "silent" state at physiological pH conditions (i.e. pH 7.4), but were activated in the acidic microenvironment of endocytic vesicles. The wormlike micelles could be employed as nanovectors for the intracellular delivery of hydrophobic drugs for cancer therapy.

AB - Wormlike micelles with intracellular pH-activating properties were developed. The micelles remained in a "silent" state at physiological pH conditions (i.e. pH 7.4), but were activated in the acidic microenvironment of endocytic vesicles. The wormlike micelles could be employed as nanovectors for the intracellular delivery of hydrophobic drugs for cancer therapy.

UR - https://www.scopus.com/pages/publications/84883333936

U2 - 10.1039/c3py00849e

DO - 10.1039/c3py00849e

M3 - 文章

AN - SCOPUS:84883333936

SN - 1759-9954

VL - 4

SP - 5052

EP - 5055

JO - Polymer Chemistry

JF - Polymer Chemistry

IS - 19

ER -

Intracellular pH-activated PEG-b-PDPA wormlike micelles for hydrophobic drug delivery

Abstract

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