Intracellular localization and cytotoxicity of spherical mesoporous silica nano-and microparticles

Qianjun He; Zhiwen Zhang; Yu Gao; Jianlin Shi; Yaping Li

doi:10.1002/smll.200900923

Intracellular localization and cytotoxicity of spherical mesoporous silica nano-and microparticles

Qianjun He
, Zhiwen Zhang
, Yu Gao
, Jianlin Shi^*
, Yaping Li

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

303 Scopus citations

Abstract

This work evaluates the cytotoxicity of spherical mesoporous silica (MS) nano-and microparticles and investigates the effects of particle size, concentration, biodegradation products of MS, residual surfactant, and surfactant removal by extraction and calcination on the cytotoxicity. The results from the intracellular localization of spherical MS nano-and microparticles with different sizes reveal the mechanism for their cytotoxicity and that the smaller particles in nanoscale are more easily endocytosed and consequently located within lysosomes.

Original language	English
Pages (from-to)	2722-2729
Number of pages	8
Journal	Small
Volume	5
Issue number	23
DOIs	https://doi.org/10.1002/smll.200900923
State	Published - 4 Dec 2009
Externally published	Yes

Keywords

Cytotoxicity
Intracellular localization
Mesoporous silica
Microparticles
Spherical nanoparticles

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10.1002/smll.200900923

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title = "Intracellular localization and cytotoxicity of spherical mesoporous silica nano-and microparticles",

abstract = "This work evaluates the cytotoxicity of spherical mesoporous silica (MS) nano-and microparticles and investigates the effects of particle size, concentration, biodegradation products of MS, residual surfactant, and surfactant removal by extraction and calcination on the cytotoxicity. The results from the intracellular localization of spherical MS nano-and microparticles with different sizes reveal the mechanism for their cytotoxicity and that the smaller particles in nanoscale are more easily endocytosed and consequently located within lysosomes.",

keywords = "Cytotoxicity, Intracellular localization, Mesoporous silica, Microparticles, Spherical nanoparticles",

author = "Qianjun He and Zhiwen Zhang and Yu Gao and Jianlin Shi and Yaping Li",

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AU - He, Qianjun

AU - Zhang, Zhiwen

AU - Gao, Yu

AU - Shi, Jianlin

AU - Li, Yaping

PY - 2009/12/4

Y1 - 2009/12/4

N2 - This work evaluates the cytotoxicity of spherical mesoporous silica (MS) nano-and microparticles and investigates the effects of particle size, concentration, biodegradation products of MS, residual surfactant, and surfactant removal by extraction and calcination on the cytotoxicity. The results from the intracellular localization of spherical MS nano-and microparticles with different sizes reveal the mechanism for their cytotoxicity and that the smaller particles in nanoscale are more easily endocytosed and consequently located within lysosomes.

AB - This work evaluates the cytotoxicity of spherical mesoporous silica (MS) nano-and microparticles and investigates the effects of particle size, concentration, biodegradation products of MS, residual surfactant, and surfactant removal by extraction and calcination on the cytotoxicity. The results from the intracellular localization of spherical MS nano-and microparticles with different sizes reveal the mechanism for their cytotoxicity and that the smaller particles in nanoscale are more easily endocytosed and consequently located within lysosomes.

KW - Cytotoxicity

KW - Intracellular localization

KW - Mesoporous silica

KW - Microparticles

KW - Spherical nanoparticles

UR - https://www.scopus.com/pages/publications/73349141425

U2 - 10.1002/smll.200900923

DO - 10.1002/smll.200900923

M3 - 文章

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AN - SCOPUS:73349141425

SN - 1613-6810

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SP - 2722

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JO - Small

JF - Small

IS - 23

ER -

Intracellular localization and cytotoxicity of spherical mesoporous silica nano-and microparticles

Abstract

Keywords

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