Interleukin-17 Family

Yuping Lai; Chen Dong

doi:10.1016/B978-0-12-374279-7.10014-1

Interleukin-17 Family

Yuping Lai, Chen Dong

School of Life Sciences

Tsinghua University

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

As potent pro-inflammatory mediators, cytokines in the interleukin-17 (IL-17) family play crucial roles in inflammation, autoimmunity, and host defense. In the past decade, substantial progresswas made in the identification of IL-17-producing cell subsets as well as the new functions of IL-17 in diseases. Here we summarize members of the IL-17 and IL-17 receptor families, focus on the recent advances in the identification of new innate IL-17-producing cells, and dissect the mechanisms by which IL-17 signaling is regulated. We conclude by discussing how IL-17 and IL-17R normally function in host defense against microbial infections or abnormally in chronic inflammatory diseases, especially psoriasis.

Original language	English
Title of host publication	Molecular Immunology
Publisher	Elsevier Inc.
Pages	534-543
Number of pages	10
Volume	2
ISBN (Print)	9780080921525
DOIs	https://doi.org/10.1016/B978-0-12-374279-7.10014-1
State	Published - 27 Apr 2016

Keywords

Antimicrobial defense
Chronic inflammatory diseases
IL-17 family
IL-17 receptors
Innate IL-17-producing cells
Psoriasis
Signaling transduction
Th17 cells

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10.1016/B978-0-12-374279-7.10014-1

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abstract = "As potent pro-inflammatory mediators, cytokines in the interleukin-17 (IL-17) family play crucial roles in inflammation, autoimmunity, and host defense. In the past decade, substantial progresswas made in the identification of IL-17-producing cell subsets as well as the new functions of IL-17 in diseases. Here we summarize members of the IL-17 and IL-17 receptor families, focus on the recent advances in the identification of new innate IL-17-producing cells, and dissect the mechanisms by which IL-17 signaling is regulated. We conclude by discussing how IL-17 and IL-17R normally function in host defense against microbial infections or abnormally in chronic inflammatory diseases, especially psoriasis.",

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N2 - As potent pro-inflammatory mediators, cytokines in the interleukin-17 (IL-17) family play crucial roles in inflammation, autoimmunity, and host defense. In the past decade, substantial progresswas made in the identification of IL-17-producing cell subsets as well as the new functions of IL-17 in diseases. Here we summarize members of the IL-17 and IL-17 receptor families, focus on the recent advances in the identification of new innate IL-17-producing cells, and dissect the mechanisms by which IL-17 signaling is regulated. We conclude by discussing how IL-17 and IL-17R normally function in host defense against microbial infections or abnormally in chronic inflammatory diseases, especially psoriasis.

AB - As potent pro-inflammatory mediators, cytokines in the interleukin-17 (IL-17) family play crucial roles in inflammation, autoimmunity, and host defense. In the past decade, substantial progresswas made in the identification of IL-17-producing cell subsets as well as the new functions of IL-17 in diseases. Here we summarize members of the IL-17 and IL-17 receptor families, focus on the recent advances in the identification of new innate IL-17-producing cells, and dissect the mechanisms by which IL-17 signaling is regulated. We conclude by discussing how IL-17 and IL-17R normally function in host defense against microbial infections or abnormally in chronic inflammatory diseases, especially psoriasis.

KW - Antimicrobial defense

KW - Chronic inflammatory diseases

KW - IL-17 family

KW - IL-17 receptors

KW - Innate IL-17-producing cells

KW - Psoriasis

KW - Signaling transduction

KW - Th17 cells

UR - https://www.scopus.com/pages/publications/85043279170

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DO - 10.1016/B978-0-12-374279-7.10014-1

M3 - 章节

AN - SCOPUS:85043279170

SN - 9780080921525

VL - 2

SP - 534

EP - 543

BT - Molecular Immunology

PB - Elsevier Inc.

ER -

Interleukin-17 Family

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Keywords

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