Interaction of naphthyl heterocycles with DNA: Effects of thiono and thio groups

Xuhong Qian; Tian Bao Huang; Dong Zhi Wei; Dong Hui Zhu; Ming Cai Fan; Wei Yao

doi:10.1039/a908787g

Interaction of naphthyl heterocycles with DNA: Effects of thiono and thio groups

Xuhong Qian^*
, Tian Bao Huang
, Dong Zhi Wei
, Dong Hui Zhu
, Ming Cai Fan
, Wei Yao

^*Corresponding author for this work

Dalian University of Technology

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

The intercalation and photocleavage of DNA by N-[β-(N′,N′-dimethylamino)ethyl]dithiono-1,8-naphthalimide (2) were extremely effective compared to the use of the oxygen-containing counterpart (1). Their photocleavage action under 366 nm UV light is proposed to proceed by electron transfer from bases to the triplet state of the naphthalimides. The enhancement of the intercalation of DNA and the photocleavage of DNA were also observed for other compounds possessing a thiono or thio group compared with their oxygen-containing counterparts.

Original language	English
Pages (from-to)	715-718
Number of pages	4
Journal	Journal of the Chemical Society. Perkin Transactions 2
Issue number	4
DOIs	https://doi.org/10.1039/a908787g
State	Published - Apr 2000
Externally published	Yes

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title = "Interaction of naphthyl heterocycles with DNA: Effects of thiono and thio groups",

abstract = "The intercalation and photocleavage of DNA by N-[β-(N′,N′-dimethylamino)ethyl]dithiono-1,8-naphthalimide (2) were extremely effective compared to the use of the oxygen-containing counterpart (1). Their photocleavage action under 366 nm UV light is proposed to proceed by electron transfer from bases to the triplet state of the naphthalimides. The enhancement of the intercalation of DNA and the photocleavage of DNA were also observed for other compounds possessing a thiono or thio group compared with their oxygen-containing counterparts.",

author = "Xuhong Qian and Huang, \{Tian Bao\} and Wei, \{Dong Zhi\} and Zhu, \{Dong Hui\} and Fan, \{Ming Cai\} and Wei Yao",

year = "2000",

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doi = "10.1039/a908787g",

language = "英语",

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journal = "Journal of the Chemical Society. Perkin Transactions 2",

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TY - JOUR

T1 - Interaction of naphthyl heterocycles with DNA

T2 - Effects of thiono and thio groups

AU - Qian, Xuhong

AU - Huang, Tian Bao

AU - Wei, Dong Zhi

AU - Zhu, Dong Hui

AU - Fan, Ming Cai

AU - Yao, Wei

PY - 2000/4

Y1 - 2000/4

N2 - The intercalation and photocleavage of DNA by N-[β-(N′,N′-dimethylamino)ethyl]dithiono-1,8-naphthalimide (2) were extremely effective compared to the use of the oxygen-containing counterpart (1). Their photocleavage action under 366 nm UV light is proposed to proceed by electron transfer from bases to the triplet state of the naphthalimides. The enhancement of the intercalation of DNA and the photocleavage of DNA were also observed for other compounds possessing a thiono or thio group compared with their oxygen-containing counterparts.

AB - The intercalation and photocleavage of DNA by N-[β-(N′,N′-dimethylamino)ethyl]dithiono-1,8-naphthalimide (2) were extremely effective compared to the use of the oxygen-containing counterpart (1). Their photocleavage action under 366 nm UV light is proposed to proceed by electron transfer from bases to the triplet state of the naphthalimides. The enhancement of the intercalation of DNA and the photocleavage of DNA were also observed for other compounds possessing a thiono or thio group compared with their oxygen-containing counterparts.

UR - https://www.scopus.com/pages/publications/0034175151

U2 - 10.1039/a908787g

DO - 10.1039/a908787g

M3 - 文章

AN - SCOPUS:0034175151

SN - 0300-9580

SP - 715

EP - 718

JO - Journal of the Chemical Society. Perkin Transactions 2

JF - Journal of the Chemical Society. Perkin Transactions 2

IS - 4

ER -

Interaction of naphthyl heterocycles with DNA: Effects of thiono and thio groups

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