Intelligent MnO2 Nanosheets Anchored with Upconversion Nanoprobes for Concurrent pH-/H2O2-Responsive UCL Imaging and Oxygen-Elevated Synergetic Therapy

Wenpei Fan; Wenbo Bu; Bo Shen; Qianjun He; Zhaowen Cui; Yanyan Liu; Xiangpeng Zheng; Kuaile Zhao; Jianlin Shi

doi:10.1002/adma.201405141

Intelligent MnO₂ Nanosheets Anchored with Upconversion Nanoprobes for Concurrent pH-/H₂O₂-Responsive UCL Imaging and Oxygen-Elevated Synergetic Therapy

Wenpei Fan
, Wenbo Bu
, Bo Shen^*
, Qianjun He
, Zhaowen Cui
, Yanyan Liu
, Xiangpeng Zheng
, Kuaile Zhao
, Jianlin Shi

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

652 Scopus citations

Abstract

Intelligent 2D theranostic nanomaterials are successfully designed based on pH-/H₂O₂-responsive MnO₂ nanosheets anchored with upconversion nanoprobes. They react with acidic H₂O₂ to generate sufficient oxygen for enhancing the synergetic radio/photodynamic therapy efficacy upon NIR light/X-ray irradiation and recover/enhance the upconversion luminescence for monitoring the therapeutic process.

Original language	English
Pages (from-to)	4155-4161
Number of pages	7
Journal	Advanced Materials
Volume	27
Issue number	28
DOIs	https://doi.org/10.1002/adma.201405141
State	Published - 1 Jul 2015
Externally published	Yes

Keywords

MnO nanosheets
synergetic therapy
tumor oxygenation
upconversion luminescen imaging
upconversion nanoprobes

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10.1002/adma.201405141

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title = "Intelligent MnO2 Nanosheets Anchored with Upconversion Nanoprobes for Concurrent pH-/H2O2-Responsive UCL Imaging and Oxygen-Elevated Synergetic Therapy",

abstract = "Intelligent 2D theranostic nanomaterials are successfully designed based on pH-/H2O2-responsive MnO2 nanosheets anchored with upconversion nanoprobes. They react with acidic H2O2 to generate sufficient oxygen for enhancing the synergetic radio/photodynamic therapy efficacy upon NIR light/X-ray irradiation and recover/enhance the upconversion luminescence for monitoring the therapeutic process.",

keywords = "MnO nanosheets, synergetic therapy, tumor oxygenation, upconversion luminescen imaging, upconversion nanoprobes",

author = "Wenpei Fan and Wenbo Bu and Bo Shen and Qianjun He and Zhaowen Cui and Yanyan Liu and Xiangpeng Zheng and Kuaile Zhao and Jianlin Shi",

note = "Publisher Copyright: {\textcopyright} 2015 WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim.",

year = "2015",

month = jul,

day = "1",

doi = "10.1002/adma.201405141",

language = "英语",

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pages = "4155--4161",

journal = "Advanced Materials",

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TY - JOUR

T1 - Intelligent MnO2 Nanosheets Anchored with Upconversion Nanoprobes for Concurrent pH-/H2O2-Responsive UCL Imaging and Oxygen-Elevated Synergetic Therapy

AU - Fan, Wenpei

AU - Bu, Wenbo

AU - Shen, Bo

AU - He, Qianjun

AU - Cui, Zhaowen

AU - Liu, Yanyan

AU - Zheng, Xiangpeng

AU - Zhao, Kuaile

AU - Shi, Jianlin

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Intelligent 2D theranostic nanomaterials are successfully designed based on pH-/H2O2-responsive MnO2 nanosheets anchored with upconversion nanoprobes. They react with acidic H2O2 to generate sufficient oxygen for enhancing the synergetic radio/photodynamic therapy efficacy upon NIR light/X-ray irradiation and recover/enhance the upconversion luminescence for monitoring the therapeutic process.

AB - Intelligent 2D theranostic nanomaterials are successfully designed based on pH-/H2O2-responsive MnO2 nanosheets anchored with upconversion nanoprobes. They react with acidic H2O2 to generate sufficient oxygen for enhancing the synergetic radio/photodynamic therapy efficacy upon NIR light/X-ray irradiation and recover/enhance the upconversion luminescence for monitoring the therapeutic process.

KW - MnO nanosheets

KW - synergetic therapy

KW - tumor oxygenation

KW - upconversion luminescen imaging

KW - upconversion nanoprobes

UR - https://www.scopus.com/pages/publications/84937035812

U2 - 10.1002/adma.201405141

DO - 10.1002/adma.201405141

M3 - 文章

C2 - 26058562

AN - SCOPUS:84937035812

SN - 0935-9648

VL - 27

SP - 4155

EP - 4161

JO - Advanced Materials

JF - Advanced Materials

IS - 28

ER -

Intelligent MnO₂ Nanosheets Anchored with Upconversion Nanoprobes for Concurrent pH-/H₂O₂-Responsive UCL Imaging and Oxygen-Elevated Synergetic Therapy

Abstract

Keywords

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