Injectable 2D MoS2-Integrated Drug Delivering Implant for Highly Efficient NIR-Triggered Synergistic Tumor Hyperthermia

Shige Wang; Yu Chen; Xiang Li; Wei Gao; Linlin Zhang; Jun Liu; Yuanyi Zheng; Hangrong Chen; Jianlin Shi

doi:10.1002/adma.201503869

Injectable 2D MoS₂-Integrated Drug Delivering Implant for Highly Efficient NIR-Triggered Synergistic Tumor Hyperthermia

Shige Wang, Yu Chen, Xiang Li, Wei Gao, Linlin Zhang, Jun Liu, Yuanyi Zheng, Hangrong Chen, Jianlin Shi

Research output: Contribution to journal › Article › peer-review

261 Scopus citations

Abstract

MoS₂ nanosheets and a doxorubicin (DOX)-containing poly (lactic-co-glycolic acid) (PLGA)/MoS₂/DOX composite implant are successfully constructed based on the unique phase-changing behavior of PLGA/MoS₂/DOX oleosol within tumors. The fast phase transformation can firmly restrict MoS₂ and DOX within tumors, and the integrated MoS₂ and DOX can endow the implant with high synergistic photothermal and chemotherapeutic efficiency against tumors.

Original language	English
Pages (from-to)	7117-7122
Number of pages	6
Journal	Advanced Materials
Volume	27
Issue number	44
DOIs	https://doi.org/10.1002/adma.201503869
State	Published - 25 Nov 2015
Externally published	Yes

Keywords

composite implants
drug delivery
molybdenum disulfides
photothermal therapies
synergistic tumor therapy

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10.1002/adma.201503869

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title = "Injectable 2D MoS2-Integrated Drug Delivering Implant for Highly Efficient NIR-Triggered Synergistic Tumor Hyperthermia",

abstract = "MoS2 nanosheets and a doxorubicin (DOX)-containing poly (lactic-co-glycolic acid) (PLGA)/MoS2/DOX composite implant are successfully constructed based on the unique phase-changing behavior of PLGA/MoS2/DOX oleosol within tumors. The fast phase transformation can firmly restrict MoS2 and DOX within tumors, and the integrated MoS2 and DOX can endow the implant with high synergistic photothermal and chemotherapeutic efficiency against tumors.",

keywords = "composite implants, drug delivery, molybdenum disulfides, photothermal therapies, synergistic tumor therapy",

author = "Shige Wang and Yu Chen and Xiang Li and Wei Gao and Linlin Zhang and Jun Liu and Yuanyi Zheng and Hangrong Chen and Jianlin Shi",

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doi = "10.1002/adma.201503869",

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T1 - Injectable 2D MoS2-Integrated Drug Delivering Implant for Highly Efficient NIR-Triggered Synergistic Tumor Hyperthermia

AU - Wang, Shige

AU - Chen, Yu

AU - Li, Xiang

AU - Gao, Wei

AU - Zhang, Linlin

AU - Liu, Jun

AU - Zheng, Yuanyi

AU - Chen, Hangrong

AU - Shi, Jianlin

PY - 2015/11/25

Y1 - 2015/11/25

N2 - MoS2 nanosheets and a doxorubicin (DOX)-containing poly (lactic-co-glycolic acid) (PLGA)/MoS2/DOX composite implant are successfully constructed based on the unique phase-changing behavior of PLGA/MoS2/DOX oleosol within tumors. The fast phase transformation can firmly restrict MoS2 and DOX within tumors, and the integrated MoS2 and DOX can endow the implant with high synergistic photothermal and chemotherapeutic efficiency against tumors.

AB - MoS2 nanosheets and a doxorubicin (DOX)-containing poly (lactic-co-glycolic acid) (PLGA)/MoS2/DOX composite implant are successfully constructed based on the unique phase-changing behavior of PLGA/MoS2/DOX oleosol within tumors. The fast phase transformation can firmly restrict MoS2 and DOX within tumors, and the integrated MoS2 and DOX can endow the implant with high synergistic photothermal and chemotherapeutic efficiency against tumors.

KW - composite implants

KW - drug delivery

KW - molybdenum disulfides

KW - photothermal therapies

KW - synergistic tumor therapy

UR - https://www.scopus.com/pages/publications/84949266679

U2 - 10.1002/adma.201503869

DO - 10.1002/adma.201503869

M3 - 文章

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AN - SCOPUS:84949266679

SN - 0935-9648

VL - 27

SP - 7117

EP - 7122

JO - Advanced Materials

JF - Advanced Materials

IS - 44

ER -

Injectable 2D MoS₂-Integrated Drug Delivering Implant for Highly Efficient NIR-Triggered Synergistic Tumor Hyperthermia

Abstract

Keywords

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