Inherent anchorages in UiO-66 nanoparticles for efficient capture of alendronate and its mediated release

Xiangyang Zhu; Jinlou Gu; Yao Wang; Bing Li; Yongsheng Li; Wenru Zhao; Jianlin Shi

doi:10.1039/c4cc02570a

Inherent anchorages in UiO-66 nanoparticles for efficient capture of alendronate and its mediated release

Xiangyang Zhu
, Jinlou Gu
, Yao Wang
, Bing Li
, Yongsheng Li
, Wenru Zhao
, Jianlin Shi^*

^*Corresponding author for this work

East China University of Science and Technology

Research output: Contribution to journal › Article › peer-review

283 Scopus citations

Abstract

Zr-based MOF nanoparticles were applied as efficient carriers for alendronate delivery, and an unprecedented drug loading capacity was achieved thanks to the inherent drug anchorages of Zr–O clusters therein. The encapsulated drug featured with a pH-dependent release profile, and inhibited the growth of cancer cells more efficiently than the free drug.

Original language	English
Pages (from-to)	8779-8782
Number of pages	4
Journal	Chemical Communications
Volume	50
Issue number	63
DOIs	https://doi.org/10.1039/c4cc02570a
State	Published - 10 Jul 2014
Externally published	Yes

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10.1039/c4cc02570a

Cite this

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title = "Inherent anchorages in UiO-66 nanoparticles for efficient capture of alendronate and its mediated release",

abstract = "Zr-based MOF nanoparticles were applied as efficient carriers for alendronate delivery, and an unprecedented drug loading capacity was achieved thanks to the inherent drug anchorages of Zr–O clusters therein. The encapsulated drug featured with a pH-dependent release profile, and inhibited the growth of cancer cells more efficiently than the free drug.",

author = "Xiangyang Zhu and Jinlou Gu and Yao Wang and Bing Li and Yongsheng Li and Wenru Zhao and Jianlin Shi",

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doi = "10.1039/c4cc02570a",

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T1 - Inherent anchorages in UiO-66 nanoparticles for efficient capture of alendronate and its mediated release

AU - Zhu, Xiangyang

AU - Gu, Jinlou

AU - Wang, Yao

AU - Li, Bing

AU - Li, Yongsheng

AU - Zhao, Wenru

AU - Shi, Jianlin

PY - 2014/7/10

Y1 - 2014/7/10

N2 - Zr-based MOF nanoparticles were applied as efficient carriers for alendronate delivery, and an unprecedented drug loading capacity was achieved thanks to the inherent drug anchorages of Zr–O clusters therein. The encapsulated drug featured with a pH-dependent release profile, and inhibited the growth of cancer cells more efficiently than the free drug.

AB - Zr-based MOF nanoparticles were applied as efficient carriers for alendronate delivery, and an unprecedented drug loading capacity was achieved thanks to the inherent drug anchorages of Zr–O clusters therein. The encapsulated drug featured with a pH-dependent release profile, and inhibited the growth of cancer cells more efficiently than the free drug.

UR - https://www.scopus.com/pages/publications/84904204482

U2 - 10.1039/c4cc02570a

DO - 10.1039/c4cc02570a

M3 - 文章

C2 - 24967656

AN - SCOPUS:84904204482

SN - 1359-7345

VL - 50

SP - 8779

EP - 8782

JO - Chemical Communications

JF - Chemical Communications

IS - 63

ER -

Inherent anchorages in UiO-66 nanoparticles for efficient capture of alendronate and its mediated release

Abstract

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