Increased insulin sensitivity and distorted mitochondrial adaptations during muscle unloading

Zhengtang Qi; Yuan Zhang; Wei Guo; Liu Ji; Shuzhe Ding

doi:10.3390/ijms131216971

Increased insulin sensitivity and distorted mitochondrial adaptations during muscle unloading

Zhengtang Qi
, Yuan Zhang
, Wei Guo
, Liu Ji
, Shuzhe Ding^*

^*Corresponding author for this work

College of Physical Education and Health

East China Normal University
Zhejiang Institute of Sports Science

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

We aimed to further investigate mitochondrial adaptations to muscle disuse and the consequent metabolic disorders. Male rats were submitted to hindlimb unloading (HU) for three weeks. Interestingly, HU increased insulin sensitivity index (ISI) and decreased blood level of triglyceride and insulin. In skeletal muscle, HU decreased expression of pyruvate dehydrogenase kinase 4 (PDK4) and its protein level in mitochondria. HU decreased mtDNA content and mitochondrial biogenesis biomarkers. Dynamin-related protein (Drp1) in mitochondria and Mfn2 mRNA level were decreased significantly by HU. Our findings provide more extensive insight into mitochondrial adaptations to muscle disuse, involving the shift of fuel utilization towards glucose, the decreased mitochondrial biogenesis and the distorted mitochondrial dynamics.

Original language	English
Pages (from-to)	16971-16985
Number of pages	15
Journal	International Journal of Molecular Sciences
Volume	13
Issue number	12
DOIs	https://doi.org/10.3390/ijms131216971
State	Published - Dec 2012

Keywords

Hindlimb unloading
Insulin sensitivity
Mitochondrial
Pyruvate dehydrogenase kinase 4
Skeletal muscle

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10.3390/ijms131216971

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title = "Increased insulin sensitivity and distorted mitochondrial adaptations during muscle unloading",

abstract = "We aimed to further investigate mitochondrial adaptations to muscle disuse and the consequent metabolic disorders. Male rats were submitted to hindlimb unloading (HU) for three weeks. Interestingly, HU increased insulin sensitivity index (ISI) and decreased blood level of triglyceride and insulin. In skeletal muscle, HU decreased expression of pyruvate dehydrogenase kinase 4 (PDK4) and its protein level in mitochondria. HU decreased mtDNA content and mitochondrial biogenesis biomarkers. Dynamin-related protein (Drp1) in mitochondria and Mfn2 mRNA level were decreased significantly by HU. Our findings provide more extensive insight into mitochondrial adaptations to muscle disuse, involving the shift of fuel utilization towards glucose, the decreased mitochondrial biogenesis and the distorted mitochondrial dynamics.",

keywords = "Hindlimb unloading, Insulin sensitivity, Mitochondrial, Pyruvate dehydrogenase kinase 4, Skeletal muscle",

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T1 - Increased insulin sensitivity and distorted mitochondrial adaptations during muscle unloading

AU - Qi, Zhengtang

AU - Zhang, Yuan

AU - Guo, Wei

AU - Ji, Liu

AU - Ding, Shuzhe

PY - 2012/12

Y1 - 2012/12

N2 - We aimed to further investigate mitochondrial adaptations to muscle disuse and the consequent metabolic disorders. Male rats were submitted to hindlimb unloading (HU) for three weeks. Interestingly, HU increased insulin sensitivity index (ISI) and decreased blood level of triglyceride and insulin. In skeletal muscle, HU decreased expression of pyruvate dehydrogenase kinase 4 (PDK4) and its protein level in mitochondria. HU decreased mtDNA content and mitochondrial biogenesis biomarkers. Dynamin-related protein (Drp1) in mitochondria and Mfn2 mRNA level were decreased significantly by HU. Our findings provide more extensive insight into mitochondrial adaptations to muscle disuse, involving the shift of fuel utilization towards glucose, the decreased mitochondrial biogenesis and the distorted mitochondrial dynamics.

AB - We aimed to further investigate mitochondrial adaptations to muscle disuse and the consequent metabolic disorders. Male rats were submitted to hindlimb unloading (HU) for three weeks. Interestingly, HU increased insulin sensitivity index (ISI) and decreased blood level of triglyceride and insulin. In skeletal muscle, HU decreased expression of pyruvate dehydrogenase kinase 4 (PDK4) and its protein level in mitochondria. HU decreased mtDNA content and mitochondrial biogenesis biomarkers. Dynamin-related protein (Drp1) in mitochondria and Mfn2 mRNA level were decreased significantly by HU. Our findings provide more extensive insight into mitochondrial adaptations to muscle disuse, involving the shift of fuel utilization towards glucose, the decreased mitochondrial biogenesis and the distorted mitochondrial dynamics.

KW - Hindlimb unloading

KW - Insulin sensitivity

KW - Mitochondrial

KW - Pyruvate dehydrogenase kinase 4

KW - Skeletal muscle

UR - https://www.scopus.com/pages/publications/84871672901

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DO - 10.3390/ijms131216971

M3 - 文章

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AN - SCOPUS:84871672901

SN - 1661-6596

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SP - 16971

EP - 16985

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 12

ER -

Increased insulin sensitivity and distorted mitochondrial adaptations during muscle unloading

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Keywords

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