Inclusion complexes of isoflavones with two commercially available dendrimers: Solubility, stability, structures, release behaviors, cytotoxicity, and anti-oxidant activities

Chen Zhao; Yitong Wang; Yunzhang Su; Hongfeng Zhang; Lingxiao Ding; Xiaofeng Yan; Di Zhao; Naimin Shao; Xiyun Ye; Yiyun Cheng

doi:10.1016/j.ijpharm.2011.09.044

Inclusion complexes of isoflavones with two commercially available dendrimers: Solubility, stability, structures, release behaviors, cytotoxicity, and anti-oxidant activities

Chen Zhao, Yitong Wang, Yunzhang Su, Hongfeng Zhang, Lingxiao Ding, Xiaofeng Yan, Di Zhao, Naimin Shao, Xiyun Ye, Yiyun Cheng

School of Life Sciences

East China Normal University

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

We prepared and characterized the inclusion complexes of daidzein with poly(amidoamine) (PAMAM) and poly(propylene imine) (PPI) dendrimers. Aqueous solubility of daidzein was significantly enhanced by both PAMAM and PPI (186- and 650-fold at 0.36 mM, respectively). Daidzein in G3 PAMAM solution is more stable than that in G4 PPI. NMR studies reveal the encapsulation of daidzein within the interior cavities of PPI through hydrophobic interactions. Daidzein exhibits a slower release behavior from PPI than that from PAMAM. PPI/daidzein complex is much more toxic than PAMAM/daidzein complex on several cell lines. PAMAM/daidzein complexes showed similar protective effect on oxidative stress-induced cytotoxicity as compared to free daidzein. These results suggest that the inclusion of daidzein with dendrimer can effectively improve the solubility, prolong the delivery, and maintain the anti-oxidant activity of daidzein. This research provides new insights into dendrimer-based drug delivery systems and will be helpful for the design of novel dendrimer/drug formulations.

Original language	English
Pages (from-to)	301-309
Number of pages	9
Journal	International Journal of Pharmaceutics
Volume	421
Issue number	2
DOIs	https://doi.org/10.1016/j.ijpharm.2011.09.044
State	Published - 15 Dec 2011

Keywords

Daidzein
Dendrimer
Isoflavones
PAMAM
PPI

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10.1016/j.ijpharm.2011.09.044

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Zhao, C., Wang, Y., Su, Y., Zhang, H., Ding, L., Yan, X., Zhao, D., Shao, N., Ye, X., & Cheng, Y. (2011). Inclusion complexes of isoflavones with two commercially available dendrimers: Solubility, stability, structures, release behaviors, cytotoxicity, and anti-oxidant activities. International Journal of Pharmaceutics, 421(2), 301-309. https://doi.org/10.1016/j.ijpharm.2011.09.044

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title = "Inclusion complexes of isoflavones with two commercially available dendrimers: Solubility, stability, structures, release behaviors, cytotoxicity, and anti-oxidant activities",

abstract = "We prepared and characterized the inclusion complexes of daidzein with poly(amidoamine) (PAMAM) and poly(propylene imine) (PPI) dendrimers. Aqueous solubility of daidzein was significantly enhanced by both PAMAM and PPI (186- and 650-fold at 0.36 mM, respectively). Daidzein in G3 PAMAM solution is more stable than that in G4 PPI. NMR studies reveal the encapsulation of daidzein within the interior cavities of PPI through hydrophobic interactions. Daidzein exhibits a slower release behavior from PPI than that from PAMAM. PPI/daidzein complex is much more toxic than PAMAM/daidzein complex on several cell lines. PAMAM/daidzein complexes showed similar protective effect on oxidative stress-induced cytotoxicity as compared to free daidzein. These results suggest that the inclusion of daidzein with dendrimer can effectively improve the solubility, prolong the delivery, and maintain the anti-oxidant activity of daidzein. This research provides new insights into dendrimer-based drug delivery systems and will be helpful for the design of novel dendrimer/drug formulations.",

keywords = "Daidzein, Dendrimer, Isoflavones, PAMAM, PPI",

author = "Chen Zhao and Yitong Wang and Yunzhang Su and Hongfeng Zhang and Lingxiao Ding and Xiaofeng Yan and Di Zhao and Naimin Shao and Xiyun Ye and Yiyun Cheng",

year = "2011",

month = dec,

day = "15",

doi = "10.1016/j.ijpharm.2011.09.044",

language = "英语",

volume = "421",

pages = "301--309",

journal = "International Journal of Pharmaceutics",

issn = "0378-5173",

publisher = "Elsevier B.V.",

number = "2",

}

Zhao, C, Wang, Y, Su, Y, Zhang, H, Ding, L, Yan, X, Zhao, D, Shao, N, Ye, X & Cheng, Y 2011, 'Inclusion complexes of isoflavones with two commercially available dendrimers: Solubility, stability, structures, release behaviors, cytotoxicity, and anti-oxidant activities', International Journal of Pharmaceutics, vol. 421, no. 2, pp. 301-309. https://doi.org/10.1016/j.ijpharm.2011.09.044

Inclusion complexes of isoflavones with two commercially available dendrimers: Solubility, stability, structures, release behaviors, cytotoxicity, and anti-oxidant activities. / Zhao, Chen; Wang, Yitong; Su, Yunzhang et al.
In: International Journal of Pharmaceutics, Vol. 421, No. 2, 15.12.2011, p. 301-309.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Inclusion complexes of isoflavones with two commercially available dendrimers

T2 - Solubility, stability, structures, release behaviors, cytotoxicity, and anti-oxidant activities

AU - Zhao, Chen

AU - Wang, Yitong

AU - Su, Yunzhang

AU - Zhang, Hongfeng

AU - Ding, Lingxiao

AU - Yan, Xiaofeng

AU - Zhao, Di

AU - Shao, Naimin

AU - Ye, Xiyun

AU - Cheng, Yiyun

PY - 2011/12/15

Y1 - 2011/12/15

N2 - We prepared and characterized the inclusion complexes of daidzein with poly(amidoamine) (PAMAM) and poly(propylene imine) (PPI) dendrimers. Aqueous solubility of daidzein was significantly enhanced by both PAMAM and PPI (186- and 650-fold at 0.36 mM, respectively). Daidzein in G3 PAMAM solution is more stable than that in G4 PPI. NMR studies reveal the encapsulation of daidzein within the interior cavities of PPI through hydrophobic interactions. Daidzein exhibits a slower release behavior from PPI than that from PAMAM. PPI/daidzein complex is much more toxic than PAMAM/daidzein complex on several cell lines. PAMAM/daidzein complexes showed similar protective effect on oxidative stress-induced cytotoxicity as compared to free daidzein. These results suggest that the inclusion of daidzein with dendrimer can effectively improve the solubility, prolong the delivery, and maintain the anti-oxidant activity of daidzein. This research provides new insights into dendrimer-based drug delivery systems and will be helpful for the design of novel dendrimer/drug formulations.

AB - We prepared and characterized the inclusion complexes of daidzein with poly(amidoamine) (PAMAM) and poly(propylene imine) (PPI) dendrimers. Aqueous solubility of daidzein was significantly enhanced by both PAMAM and PPI (186- and 650-fold at 0.36 mM, respectively). Daidzein in G3 PAMAM solution is more stable than that in G4 PPI. NMR studies reveal the encapsulation of daidzein within the interior cavities of PPI through hydrophobic interactions. Daidzein exhibits a slower release behavior from PPI than that from PAMAM. PPI/daidzein complex is much more toxic than PAMAM/daidzein complex on several cell lines. PAMAM/daidzein complexes showed similar protective effect on oxidative stress-induced cytotoxicity as compared to free daidzein. These results suggest that the inclusion of daidzein with dendrimer can effectively improve the solubility, prolong the delivery, and maintain the anti-oxidant activity of daidzein. This research provides new insights into dendrimer-based drug delivery systems and will be helpful for the design of novel dendrimer/drug formulations.

KW - Daidzein

KW - Dendrimer

KW - Isoflavones

KW - PAMAM

KW - PPI

UR - https://www.scopus.com/pages/publications/81755173466

U2 - 10.1016/j.ijpharm.2011.09.044

DO - 10.1016/j.ijpharm.2011.09.044

M3 - 文章

C2 - 22001794

AN - SCOPUS:81755173466

SN - 0378-5173

VL - 421

SP - 301

EP - 309

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

IS - 2

ER -

Inclusion complexes of isoflavones with two commercially available dendrimers: Solubility, stability, structures, release behaviors, cytotoxicity, and anti-oxidant activities

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Keywords

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