In vivo monitoring of local pH values in a live rat brain based on the design of a specific electroactive molecule for H+

Fan Zhao; Limin Zhang; Anwei Zhu; Guoyue Shi; Yang Tian

doi:10.1039/c5cc09540a

In vivo monitoring of local pH values in a live rat brain based on the design of a specific electroactive molecule for H⁺

Fan Zhao
, Limin Zhang
, Anwei Zhu
, Guoyue Shi^*
, Yang Tian

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

East China Normal University

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

pH plays an important role in the biochemical, ion-regulatory, or electrical machinery of nerve and glial cells, and is considered to be related to a number of degenerative diseases. Herein, we first develop a two-channel electrochemical ratiometric biosensor for local pH determination in a live rat brain, and report the accurate pH values in the different regions of live brains upon global cerebral ischemia.

Original language	English
Pages (from-to)	3717-3720
Number of pages	4
Journal	Chemical Communications
Volume	52
Issue number	18
DOIs	https://doi.org/10.1039/c5cc09540a
State	Published - 2016

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10.1039/c5cc09540a

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title = "In vivo monitoring of local pH values in a live rat brain based on the design of a specific electroactive molecule for H+",

abstract = "pH plays an important role in the biochemical, ion-regulatory, or electrical machinery of nerve and glial cells, and is considered to be related to a number of degenerative diseases. Herein, we first develop a two-channel electrochemical ratiometric biosensor for local pH determination in a live rat brain, and report the accurate pH values in the different regions of live brains upon global cerebral ischemia.",

author = "Fan Zhao and Limin Zhang and Anwei Zhu and Guoyue Shi and Yang Tian",

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AU - Zhao, Fan

AU - Zhang, Limin

AU - Zhu, Anwei

AU - Shi, Guoyue

AU - Tian, Yang

PY - 2016

Y1 - 2016

N2 - pH plays an important role in the biochemical, ion-regulatory, or electrical machinery of nerve and glial cells, and is considered to be related to a number of degenerative diseases. Herein, we first develop a two-channel electrochemical ratiometric biosensor for local pH determination in a live rat brain, and report the accurate pH values in the different regions of live brains upon global cerebral ischemia.

AB - pH plays an important role in the biochemical, ion-regulatory, or electrical machinery of nerve and glial cells, and is considered to be related to a number of degenerative diseases. Herein, we first develop a two-channel electrochemical ratiometric biosensor for local pH determination in a live rat brain, and report the accurate pH values in the different regions of live brains upon global cerebral ischemia.

UR - https://www.scopus.com/pages/publications/84959231754

U2 - 10.1039/c5cc09540a

DO - 10.1039/c5cc09540a

M3 - 文章

AN - SCOPUS:84959231754

SN - 1359-7345

VL - 52

SP - 3717

EP - 3720

JO - Chemical Communications

JF - Chemical Communications

IS - 18

ER -

In vivo monitoring of local pH values in a live rat brain based on the design of a specific electroactive molecule for H⁺

Abstract

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