Imaging of lysosomal pH changes with a fluorescent sensor containing a novel lysosome-locating group

Hao Zhu; Jiangli Fan; Qunli Xu; Honglin Li; Jingyun Wang; Pan Gao; Xiaojun Peng

doi:10.1039/c2cc36785h

Imaging of lysosomal pH changes with a fluorescent sensor containing a novel lysosome-locating group

Hao Zhu
, Jiangli Fan
, Qunli Xu
, Honglin Li
, Jingyun Wang
, Pan Gao
, Xiaojun Peng^*

^*Corresponding author for this work

Dalian University of Technology

Research output: Contribution to journal › Article › peer-review

244 Scopus citations

Abstract

Rlyso, a highly selective and sensitive pH sensor, can stain lysosomes with a novel lysosome-locating group, methylcarbitol.Rlysowas successfully used to detect lysosomal pH changes during apoptosis or induced by chloroquine while avoiding the “alkalizing effect” on lysosomes of current lysosomal probes with nitrogen-containing sidechains.

Original language	English
Pages (from-to)	11766-11768
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	96
DOIs	https://doi.org/10.1039/c2cc36785h
State	Published - 7 Nov 2012
Externally published	Yes

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10.1039/c2cc36785h

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title = "Imaging of lysosomal pH changes with a fluorescent sensor containing a novel lysosome-locating group",

abstract = "Rlyso, a highly selective and sensitive pH sensor, can stain lysosomes with a novel lysosome-locating group, methylcarbitol.Rlysowas successfully used to detect lysosomal pH changes during apoptosis or induced by chloroquine while avoiding the “alkalizing effect” on lysosomes of current lysosomal probes with nitrogen-containing sidechains.",

author = "Hao Zhu and Jiangli Fan and Qunli Xu and Honglin Li and Jingyun Wang and Pan Gao and Xiaojun Peng",

year = "2012",

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doi = "10.1039/c2cc36785h",

language = "英语",

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pages = "11766--11768",

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T1 - Imaging of lysosomal pH changes with a fluorescent sensor containing a novel lysosome-locating group

AU - Zhu, Hao

AU - Fan, Jiangli

AU - Xu, Qunli

AU - Li, Honglin

AU - Wang, Jingyun

AU - Gao, Pan

AU - Peng, Xiaojun

PY - 2012/11/7

Y1 - 2012/11/7

N2 - Rlyso, a highly selective and sensitive pH sensor, can stain lysosomes with a novel lysosome-locating group, methylcarbitol.Rlysowas successfully used to detect lysosomal pH changes during apoptosis or induced by chloroquine while avoiding the “alkalizing effect” on lysosomes of current lysosomal probes with nitrogen-containing sidechains.

AB - Rlyso, a highly selective and sensitive pH sensor, can stain lysosomes with a novel lysosome-locating group, methylcarbitol.Rlysowas successfully used to detect lysosomal pH changes during apoptosis or induced by chloroquine while avoiding the “alkalizing effect” on lysosomes of current lysosomal probes with nitrogen-containing sidechains.

UR - https://www.scopus.com/pages/publications/84868541026

U2 - 10.1039/c2cc36785h

DO - 10.1039/c2cc36785h

M3 - 文章

C2 - 23114612

AN - SCOPUS:84868541026

SN - 1359-7345

VL - 48

SP - 11766

EP - 11768

JO - Chemical Communications

JF - Chemical Communications

IS - 96

ER -

Imaging of lysosomal pH changes with a fluorescent sensor containing a novel lysosome-locating group

Abstract

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