IL-17 family cytokines in inflammatory or autoimmune skin diseases

Baida Kong, Yuping Lai

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

4 Scopus citations

Abstract

As potent pro-inflammatory mediators, IL-17 family cytokines play crucial roles in the pathogenesis of various inflammatory and autoimmune skin disorders. Although substantial progress has been achieved in understanding the pivotal role of IL-17A signaling in psoriasis, leading to the development of highly effective biologics, the functions of other IL-17 family members in inflammatory or autoimmune skin diseases remain less explored. In this review, we provide a comprehensive overview of IL-17 family cytokines and their receptors, with a particular focus on the recent advancements in identifying cellular sources, receptors and signaling pathways regulated by these cytokines. At the end, we discuss how the aberrant functions of IL-17 family cytokines contribute to the pathogenesis of diverse inflammatory or autoimmune skin diseases.

Original languageEnglish
Title of host publicationAdvances in Immunology
EditorsFrederick W. Alt, Kenneth M. Murphy
PublisherAcademic Press Inc.
Pages21-49
Number of pages29
ISBN (Print)9780443295065
DOIs
StatePublished - Jan 2024

Publication series

NameAdvances in Immunology
Volume163
ISSN (Print)0065-2776
ISSN (Electronic)1557-8445

Keywords

  • IL-17 family cytokines
  • Inflammatory/autoimmune skin disorders
  • Receptors for IL-17 cytokines
  • Signaling transduction

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