Hydrolysis of plasmid DNA and RNA by amino alkyl naphthalimide as metal-free artificial nuclease

Qing Yang; Jianqiang Xu; Yuanshe Sun; Zhigang Li; Yonggang Li; Xuhong Qian

doi:10.1016/j.bmcl.2005.11.020

Hydrolysis of plasmid DNA and RNA by amino alkyl naphthalimide as metal-free artificial nuclease

Qing Yang^*
, Jianqiang Xu
, Yuanshe Sun
, Zhigang Li
, Yonggang Li
, Xuhong Qian

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

A strategy of dimethylamino alkyldiimide conjugated with an intercalator of naphthalimide for hydrolysis of DNA was suggested and evaluated. 4 can hydrolyze 4 kb plasmid DNA into 2 kb fragments with GC and GG selectivity, which represents a novel example of sequence- or site-selective metal-free DNA artificial nuclease. Results also show it could hydrolyze RNA efficiently.

Original language	English
Pages (from-to)	803-806
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	16
Issue number	4
DOIs	https://doi.org/10.1016/j.bmcl.2005.11.020
State	Published - 15 Feb 2006
Externally published	Yes

Keywords

DNA cleavage
Hydrolysis
Intercalator
Naphthalimide
RNA
Selectivity

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10.1016/j.bmcl.2005.11.020

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title = "Hydrolysis of plasmid DNA and RNA by amino alkyl naphthalimide as metal-free artificial nuclease",

abstract = "A strategy of dimethylamino alkyldiimide conjugated with an intercalator of naphthalimide for hydrolysis of DNA was suggested and evaluated. 4 can hydrolyze 4 kb plasmid DNA into 2 kb fragments with GC and GG selectivity, which represents a novel example of sequence- or site-selective metal-free DNA artificial nuclease. Results also show it could hydrolyze RNA efficiently.",

keywords = "DNA cleavage, Hydrolysis, Intercalator, Naphthalimide, RNA, Selectivity",

author = "Qing Yang and Jianqiang Xu and Yuanshe Sun and Zhigang Li and Yonggang Li and Xuhong Qian",

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T1 - Hydrolysis of plasmid DNA and RNA by amino alkyl naphthalimide as metal-free artificial nuclease

AU - Yang, Qing

AU - Xu, Jianqiang

AU - Sun, Yuanshe

AU - Li, Zhigang

AU - Li, Yonggang

AU - Qian, Xuhong

PY - 2006/2/15

Y1 - 2006/2/15

N2 - A strategy of dimethylamino alkyldiimide conjugated with an intercalator of naphthalimide for hydrolysis of DNA was suggested and evaluated. 4 can hydrolyze 4 kb plasmid DNA into 2 kb fragments with GC and GG selectivity, which represents a novel example of sequence- or site-selective metal-free DNA artificial nuclease. Results also show it could hydrolyze RNA efficiently.

AB - A strategy of dimethylamino alkyldiimide conjugated with an intercalator of naphthalimide for hydrolysis of DNA was suggested and evaluated. 4 can hydrolyze 4 kb plasmid DNA into 2 kb fragments with GC and GG selectivity, which represents a novel example of sequence- or site-selective metal-free DNA artificial nuclease. Results also show it could hydrolyze RNA efficiently.

KW - DNA cleavage

KW - Hydrolysis

KW - Intercalator

KW - Naphthalimide

KW - RNA

KW - Selectivity

UR - https://www.scopus.com/pages/publications/30344459414

U2 - 10.1016/j.bmcl.2005.11.020

DO - 10.1016/j.bmcl.2005.11.020

M3 - 文章

C2 - 16314096

AN - SCOPUS:30344459414

SN - 0960-894X

VL - 16

SP - 803

EP - 806

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 4

ER -

Hydrolysis of plasmid DNA and RNA by amino alkyl naphthalimide as metal-free artificial nuclease

Abstract

Keywords

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