Hollow Microporous Organic Nanospheres with an Organocatalyst and a Metal Catalyst for Tandem Reactions

Amino-functionalized hollow microporous organic nanospheres supported palladium catalysts (Pd@NH₂-H-MONs) are prepared via the integration of hyper-crosslinking induced self-assembly strategy and a simple impregnation method by employing polylactide-b-poly(Boc-aminoethyl acrylamide)-b-polystyrene (PLA-b-PBOCa-b-PS) triblock copolymers as precursors, in which Pd nanoparticles are uniformly anchored on NH₂-H-MONs based on the strong interaction between Pd nanoparticles and amino functional groups. Combining with the unique micro/mesoporous structure derived from hyper-crosslinking shell and the degradation of PLA block, the coexistence of free amine moieties produced by the deprotection of PBOCa block and well-dispersed Pd nanoparticles endows the Pd@NH₂-H-MONs with excellent catalysis activity for various cascade reactions. The present strategy opens a novel avenue for the multifunctional H-MONs acting as a superior candidate for the heterogeneous tandem catalysis reactions.