Highly Thiolated Dendritic Mesoporous Silica Nanoparticles with High-Content Gold as Nanozymes: The Nano-Gold Size Matters

Mohammad Kalantari; Trisha Ghosh; Yang Liu; Jun Zhang; Jin Zou; Chang Lei; Chengzhong Yu

doi:10.1021/acsami.9b01527

Highly Thiolated Dendritic Mesoporous Silica Nanoparticles with High-Content Gold as Nanozymes: The Nano-Gold Size Matters

Mohammad Kalantari
, Trisha Ghosh
, Yang Liu
, Jun Zhang
, Jin Zou
, Chang Lei^*
, Chengzhong Yu

^*Corresponding author for this work

University of Queensland

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

Thiolated dendritic mesoporous silica nanoparticles (T-DMSNs) with ultrahigh density of thiol groups (284.6 ± 9 μmol g ^-1 ) are synthesized and used to load gold nanoparticles with tunable sizes (1.2-2.7 nm) and high content (34.0 wt %). It is demonstrated that the size of gold nanoparticles has a significant impact on their peroxidase-mimicking activity. At an optimized size of 1.9 nm, T-DMSNs@Au exhibits the highest activity. Our contribution provides new insights into the rational design of nanozymes for future applications.

Original language	English
Pages (from-to)	13264-13272
Number of pages	9
Journal	ACS Applied Materials and Interfaces
Volume	11
Issue number	14
DOIs	https://doi.org/10.1021/acsami.9b01527
State	Published - 10 Apr 2019
Externally published	Yes

Keywords

dendritic
mesoporous silica
nano-gold
nanozyme
thiol

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10.1021/acsami.9b01527

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title = "Highly Thiolated Dendritic Mesoporous Silica Nanoparticles with High-Content Gold as Nanozymes: The Nano-Gold Size Matters",

abstract = " Thiolated dendritic mesoporous silica nanoparticles (T-DMSNs) with ultrahigh density of thiol groups (284.6 ± 9 μmol g -1 ) are synthesized and used to load gold nanoparticles with tunable sizes (1.2-2.7 nm) and high content (34.0 wt \%). It is demonstrated that the size of gold nanoparticles has a significant impact on their peroxidase-mimicking activity. At an optimized size of 1.9 nm, T-DMSNs@Au exhibits the highest activity. Our contribution provides new insights into the rational design of nanozymes for future applications.",

keywords = "dendritic, mesoporous silica, nano-gold, nanozyme, thiol",

author = "Mohammad Kalantari and Trisha Ghosh and Yang Liu and Jun Zhang and Jin Zou and Chang Lei and Chengzhong Yu",

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doi = "10.1021/acsami.9b01527",

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T2 - The Nano-Gold Size Matters

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AU - Ghosh, Trisha

AU - Liu, Yang

AU - Zhang, Jun

AU - Zou, Jin

AU - Lei, Chang

AU - Yu, Chengzhong

PY - 2019/4/10

Y1 - 2019/4/10

N2 - Thiolated dendritic mesoporous silica nanoparticles (T-DMSNs) with ultrahigh density of thiol groups (284.6 ± 9 μmol g -1 ) are synthesized and used to load gold nanoparticles with tunable sizes (1.2-2.7 nm) and high content (34.0 wt %). It is demonstrated that the size of gold nanoparticles has a significant impact on their peroxidase-mimicking activity. At an optimized size of 1.9 nm, T-DMSNs@Au exhibits the highest activity. Our contribution provides new insights into the rational design of nanozymes for future applications.

AB - Thiolated dendritic mesoporous silica nanoparticles (T-DMSNs) with ultrahigh density of thiol groups (284.6 ± 9 μmol g -1 ) are synthesized and used to load gold nanoparticles with tunable sizes (1.2-2.7 nm) and high content (34.0 wt %). It is demonstrated that the size of gold nanoparticles has a significant impact on their peroxidase-mimicking activity. At an optimized size of 1.9 nm, T-DMSNs@Au exhibits the highest activity. Our contribution provides new insights into the rational design of nanozymes for future applications.

KW - dendritic

KW - mesoporous silica

KW - nano-gold

KW - nanozyme

KW - thiol

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AN - SCOPUS:85064132845

SN - 1944-8244

VL - 11

SP - 13264

EP - 13272

JO - ACS Applied Materials and Interfaces

JF - ACS Applied Materials and Interfaces

IS - 14

ER -

Highly Thiolated Dendritic Mesoporous Silica Nanoparticles with High-Content Gold as Nanozymes: The Nano-Gold Size Matters

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Keywords

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