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Highly Stereoselective Direct Construction of Diaryl-Substituted Cyclobutanes

  • Xiang Yang Song
  • , Liu Peng Zhao
  • , Lijia Wang*
  • , Yong Tang
  • *Corresponding author for this work
  • CAS - Shanghai Institute of Organic Chemistry

Research output: Contribution to journalArticlepeer-review

Abstract

A copper catalyzed stereoselective [2+2] cyclization has been developed, providing a concise protocol to the direct construction of diaryl-substituted cyclobutanes in up to 99% yield with up to >95/5 dr. Meanwhile, the enantioselective version of this reaction has also been achieved, leading to a series of optically active diaryl-substituted cyclobutanes with up to 94% ee.

Original languageEnglish
Pages (from-to)259-262
Number of pages4
JournalChinese Journal of Chemistry
Volume38
Issue number3
DOIs
StatePublished - 1 Mar 2020

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