TY - JOUR
T1 - Highly ordered nanocavity as photonic-plasmonic-polaritonic resonator for single molecule miRNA SERS detection
AU - Tian, Zheng
AU - Xu, Dawei
AU - Yang, Shenbo
AU - Wang, Bing
AU - Zhang, Zhonghai
N1 - Publisher Copyright:
© 2024 Elsevier B.V.
PY - 2024/6/15
Y1 - 2024/6/15
N2 - Strong light-matter coupling between molecules and electromagnetic field lead to the formation of hybrid polaritonic states for surface enhanced Raman scattering (SERS) detection. However, owing to the inefficient interaction between zero-point fluctuations of photons/plasmons and molecular electronic transitions, the Raman enhancement is limited in relative low levels. Here, we propose and fabricate a TiOx/Cu2-xSe/R6G nanocavity based photonic-plasmonic-polaritonic resonator for single molecular SERS detection. Through precisely matching the energy levels of illuminated photon, generated plasmon, and molecular polariton, an extremely high Raman enhancement factor of 2.6 × 109 is implemented. The rationally designed SERS substrate allows sensitive detection of miRNA-21 in single molecular level with a detection limit of 1.58 aM. The hybrid SERS mechanism both from electromagnetic and chemical perspectives in this photonic-plasmonic-polaritonic resonance strategy provides insight into polaritonic semiconductor systems, thus paving the way for new experimental possibilities in light-matter hybrids.
AB - Strong light-matter coupling between molecules and electromagnetic field lead to the formation of hybrid polaritonic states for surface enhanced Raman scattering (SERS) detection. However, owing to the inefficient interaction between zero-point fluctuations of photons/plasmons and molecular electronic transitions, the Raman enhancement is limited in relative low levels. Here, we propose and fabricate a TiOx/Cu2-xSe/R6G nanocavity based photonic-plasmonic-polaritonic resonator for single molecular SERS detection. Through precisely matching the energy levels of illuminated photon, generated plasmon, and molecular polariton, an extremely high Raman enhancement factor of 2.6 × 109 is implemented. The rationally designed SERS substrate allows sensitive detection of miRNA-21 in single molecular level with a detection limit of 1.58 aM. The hybrid SERS mechanism both from electromagnetic and chemical perspectives in this photonic-plasmonic-polaritonic resonance strategy provides insight into polaritonic semiconductor systems, thus paving the way for new experimental possibilities in light-matter hybrids.
UR - https://www.scopus.com/pages/publications/85188502311
U2 - 10.1016/j.bios.2024.116231
DO - 10.1016/j.bios.2024.116231
M3 - 文章
C2 - 38513540
AN - SCOPUS:85188502311
SN - 0956-5663
VL - 254
JO - Biosensors and Bioelectronics
JF - Biosensors and Bioelectronics
M1 - 116231
ER -