Highly enantioselective tandem cycloisomerization/Diels-Alder reaction of 2-(1-alkynyl)-2-alken-1-ones and enals: dual catalysis with platinum and amines

Herein, we disclosed a highly efficient strategy of enantioselective synthesis of 2,3-furan-fused carbocycles bearing three-contiguous stereocenters. This transformation is catalyzed by dual catalysis of PtCl₄/chiral aminesviatandem dehydrogenative annulation/Diels-Alder reaction of 2-(1-alkynyl)-2-alken-1-ones and enals. Thein situgeneration of the furan-basedortho-quinodimethane intermediates and the iminium activation of enals are crucial to this transformation.