Highly efficient photoinduced DNA cleavage by naphthopyrone hydroperoxides

Zhi Fu Tao; Xuhong Qian; Mingcai Fan

doi:10.1246/bcsj.72.1571

Highly efficient photoinduced DNA cleavage by naphthopyrone hydroperoxides

Zhi Fu Tao^*
, Xuhong Qian
, Mingcai Fan

^*Corresponding author for this work

East China University of Science and Technology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A variety of naphthopyrone hydroperoxides as novel photochemical DNA cleavers were synthesized and evaluated. Their photochemical DNA-cleaving abilities depend on skeleton arrangement of the naphthopyrone core and are much more efficient than those of the reported 1,8-naphthalenedicarboximide analog. The DNA-cleaving mechanism by these new hydroperoxides probably mainly involves hydroxyl radicals, indicating that naphthopyrone hydroperoxides may be able to serve as a new class of intercalating photo- Fenton reagents.

Original language	English
Pages (from-to)	1571-1574
Number of pages	4
Journal	Bulletin of the Chemical Society of Japan
Volume	72
Issue number	7
DOIs	https://doi.org/10.1246/bcsj.72.1571
State	Published - Jul 1999
Externally published	Yes

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title = "Highly efficient photoinduced DNA cleavage by naphthopyrone hydroperoxides",

abstract = "A variety of naphthopyrone hydroperoxides as novel photochemical DNA cleavers were synthesized and evaluated. Their photochemical DNA-cleaving abilities depend on skeleton arrangement of the naphthopyrone core and are much more efficient than those of the reported 1,8-naphthalenedicarboximide analog. The DNA-cleaving mechanism by these new hydroperoxides probably mainly involves hydroxyl radicals, indicating that naphthopyrone hydroperoxides may be able to serve as a new class of intercalating photo- Fenton reagents.",

author = "Tao, \{Zhi Fu\} and Xuhong Qian and Mingcai Fan",

year = "1999",

month = jul,

doi = "10.1246/bcsj.72.1571",

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pages = "1571--1574",

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T1 - Highly efficient photoinduced DNA cleavage by naphthopyrone hydroperoxides

AU - Tao, Zhi Fu

AU - Qian, Xuhong

AU - Fan, Mingcai

PY - 1999/7

Y1 - 1999/7

N2 - A variety of naphthopyrone hydroperoxides as novel photochemical DNA cleavers were synthesized and evaluated. Their photochemical DNA-cleaving abilities depend on skeleton arrangement of the naphthopyrone core and are much more efficient than those of the reported 1,8-naphthalenedicarboximide analog. The DNA-cleaving mechanism by these new hydroperoxides probably mainly involves hydroxyl radicals, indicating that naphthopyrone hydroperoxides may be able to serve as a new class of intercalating photo- Fenton reagents.

AB - A variety of naphthopyrone hydroperoxides as novel photochemical DNA cleavers were synthesized and evaluated. Their photochemical DNA-cleaving abilities depend on skeleton arrangement of the naphthopyrone core and are much more efficient than those of the reported 1,8-naphthalenedicarboximide analog. The DNA-cleaving mechanism by these new hydroperoxides probably mainly involves hydroxyl radicals, indicating that naphthopyrone hydroperoxides may be able to serve as a new class of intercalating photo- Fenton reagents.

UR - https://www.scopus.com/pages/publications/0032764245

U2 - 10.1246/bcsj.72.1571

DO - 10.1246/bcsj.72.1571

M3 - 文章

AN - SCOPUS:0032764245

SN - 0009-2673

VL - 72

SP - 1571

EP - 1574

JO - Bulletin of the Chemical Society of Japan

JF - Bulletin of the Chemical Society of Japan

IS - 7

ER -

Highly efficient photoinduced DNA cleavage by naphthopyrone hydroperoxides

Abstract

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