Highly-efficient DNA photocleavers with long wavelength absorptions: Thio-heterocyclic fused naphthalimides containing aminoalkyl side chains

Xuhong Qian; Yonggang Li; Yufang Xu; Yan Liu; Baoyuan Qu

doi:10.1016/j.bmcl.2004.02.059

Highly-efficient DNA photocleavers with long wavelength absorptions: Thio-heterocyclic fused naphthalimides containing aminoalkyl side chains

Xuhong Qian^*
, Yonggang Li
, Yufang Xu
, Yan Liu
, Baoyuan Qu

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

Thio-heterocyclic fused naphthalimides with aminoalkyl side chains were designed, synthesized and evaluated. These compounds have long wavelength absorptions and binding affinities to Calf thymus DNA. They could photodamage supercoiled pBR322 DNA from form I (closed) to II (nicked) at a concentration as low as 0.5μM and to form III (linear) at a concentration of 50μM. A possible mechanism of superoxide anion was provided.

Original language	English
Pages (from-to)	2665-2668
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	14
Issue number	10
DOIs	https://doi.org/10.1016/j.bmcl.2004.02.059
State	Published - 17 May 2004
Externally published	Yes

Keywords

DNA photocleaver heterocycle

Access to Document

10.1016/j.bmcl.2004.02.059

Cite this

@article{b0e674d1934a48718279e70ea9b533fc,

title = "Highly-efficient DNA photocleavers with long wavelength absorptions: Thio-heterocyclic fused naphthalimides containing aminoalkyl side chains",

abstract = "Thio-heterocyclic fused naphthalimides with aminoalkyl side chains were designed, synthesized and evaluated. These compounds have long wavelength absorptions and binding affinities to Calf thymus DNA. They could photodamage supercoiled pBR322 DNA from form I (closed) to II (nicked) at a concentration as low as 0.5μM and to form III (linear) at a concentration of 50μM. A possible mechanism of superoxide anion was provided.",

keywords = "DNA photocleaver heterocycle",

author = "Xuhong Qian and Yonggang Li and Yufang Xu and Yan Liu and Baoyuan Qu",

year = "2004",

month = may,

day = "17",

doi = "10.1016/j.bmcl.2004.02.059",

language = "英语",

volume = "14",

pages = "2665--2668",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd",

number = "10",

}

TY - JOUR

T1 - Highly-efficient DNA photocleavers with long wavelength absorptions

T2 - Thio-heterocyclic fused naphthalimides containing aminoalkyl side chains

AU - Qian, Xuhong

AU - Li, Yonggang

AU - Xu, Yufang

AU - Liu, Yan

AU - Qu, Baoyuan

PY - 2004/5/17

Y1 - 2004/5/17

N2 - Thio-heterocyclic fused naphthalimides with aminoalkyl side chains were designed, synthesized and evaluated. These compounds have long wavelength absorptions and binding affinities to Calf thymus DNA. They could photodamage supercoiled pBR322 DNA from form I (closed) to II (nicked) at a concentration as low as 0.5μM and to form III (linear) at a concentration of 50μM. A possible mechanism of superoxide anion was provided.

AB - Thio-heterocyclic fused naphthalimides with aminoalkyl side chains were designed, synthesized and evaluated. These compounds have long wavelength absorptions and binding affinities to Calf thymus DNA. They could photodamage supercoiled pBR322 DNA from form I (closed) to II (nicked) at a concentration as low as 0.5μM and to form III (linear) at a concentration of 50μM. A possible mechanism of superoxide anion was provided.

KW - DNA photocleaver heterocycle

UR - https://www.scopus.com/pages/publications/1942502386

U2 - 10.1016/j.bmcl.2004.02.059

DO - 10.1016/j.bmcl.2004.02.059

M3 - 文章

C2 - 15109674

AN - SCOPUS:1942502386

SN - 0960-894X

VL - 14

SP - 2665

EP - 2668

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 10

ER -

Highly-efficient DNA photocleavers with long wavelength absorptions: Thio-heterocyclic fused naphthalimides containing aminoalkyl side chains

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this