Highly efficient complexation of sanguinarine alkaloid by carboxylatopillar[6]arene: PK a shift, increased solubility and enhanced antibacterial activity

Guchuan Ping; Yiliang Wang; Lingyun Shen; Yuting Wang; Xiaoshi Hu; Junyi Chen; Bingwen Hu; Lei Cui; Qingbin Meng; Chunju Li

doi:10.1039/c7cc02799k

Highly efficient complexation of sanguinarine alkaloid by carboxylatopillar[6]arene: PK _a shift, increased solubility and enhanced antibacterial activity

Guchuan Ping, Yiliang Wang, Lingyun Shen, Yuting Wang, Xiaoshi Hu, Junyi Chen, Bingwen Hu, Lei Cui, Qingbin Meng, Chunju Li

School of Physics and Electronic Science

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Encapsulation of a physiologically active substance, sanguinarine (SA), by a water soluble carboxylatopillar[6]arene (CP6A), is described. The efficient complexation by CP6A, giving a K_a value of (2.4 ± 0.3) × 10⁵ M^-1 in pH 7.4, served to increase the water solubility by 4.3-fold, cause a 2.02 shift in pK_a, and enhance the antibacterial activity of SA.

Original language	English
Pages (from-to)	7381-7384
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	53
DOIs	https://doi.org/10.1039/c7cc02799k
State	Published - 2017

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@article{a8c70a7b26714e288615819d80850a2c,

title = "Highly efficient complexation of sanguinarine alkaloid by carboxylatopillar[6]arene: PK a shift, increased solubility and enhanced antibacterial activity",

abstract = "Encapsulation of a physiologically active substance, sanguinarine (SA), by a water soluble carboxylatopillar[6]arene (CP6A), is described. The efficient complexation by CP6A, giving a Ka value of (2.4 ± 0.3) × 105 M-1 in pH 7.4, served to increase the water solubility by 4.3-fold, cause a 2.02 shift in pKa, and enhance the antibacterial activity of SA.",

author = "Guchuan Ping and Yiliang Wang and Lingyun Shen and Yuting Wang and Xiaoshi Hu and Junyi Chen and Bingwen Hu and Lei Cui and Qingbin Meng and Chunju Li",

note = "Publisher Copyright: {\textcopyright} 2017 The Royal Society of Chemistry.",

year = "2017",

doi = "10.1039/c7cc02799k",

language = "英语",

volume = "53",

pages = "7381--7384",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "53",

}

TY - JOUR

T1 - Highly efficient complexation of sanguinarine alkaloid by carboxylatopillar[6]arene

T2 - PK a shift, increased solubility and enhanced antibacterial activity

AU - Ping, Guchuan

AU - Wang, Yiliang

AU - Shen, Lingyun

AU - Wang, Yuting

AU - Hu, Xiaoshi

AU - Chen, Junyi

AU - Hu, Bingwen

AU - Cui, Lei

AU - Meng, Qingbin

AU - Li, Chunju

PY - 2017

Y1 - 2017

N2 - Encapsulation of a physiologically active substance, sanguinarine (SA), by a water soluble carboxylatopillar[6]arene (CP6A), is described. The efficient complexation by CP6A, giving a Ka value of (2.4 ± 0.3) × 105 M-1 in pH 7.4, served to increase the water solubility by 4.3-fold, cause a 2.02 shift in pKa, and enhance the antibacterial activity of SA.

AB - Encapsulation of a physiologically active substance, sanguinarine (SA), by a water soluble carboxylatopillar[6]arene (CP6A), is described. The efficient complexation by CP6A, giving a Ka value of (2.4 ± 0.3) × 105 M-1 in pH 7.4, served to increase the water solubility by 4.3-fold, cause a 2.02 shift in pKa, and enhance the antibacterial activity of SA.

UR - https://www.scopus.com/pages/publications/85021689487

U2 - 10.1039/c7cc02799k

DO - 10.1039/c7cc02799k

M3 - 文章

C2 - 28613312

AN - SCOPUS:85021689487

SN - 1359-7345

VL - 53

SP - 7381

EP - 7384

JO - Chemical Communications

JF - Chemical Communications

IS - 53

ER -

Highly efficient complexation of sanguinarine alkaloid by carboxylatopillar[6]arene: PK _a shift, increased solubility and enhanced antibacterial activity

Abstract

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