Highly efficient complexation of sanguinarine alkaloid by carboxylatopillar[6]arene: PK a shift, increased solubility and enhanced antibacterial activity

Guchuan Ping; Yiliang Wang; Lingyun Shen; Yuting Wang; Xiaoshi Hu; Junyi Chen; Bingwen Hu; Lei Cui; Qingbin Meng; Chunju Li

doi:10.1039/c7cc02799k

Highly efficient complexation of sanguinarine alkaloid by carboxylatopillar[6]arene: PK _a shift, increased solubility and enhanced antibacterial activity

Guchuan Ping
, Yiliang Wang
, Lingyun Shen
, Yuting Wang
, Xiaoshi Hu
, Junyi Chen
, Bingwen Hu
, Lei Cui^*
, Qingbin Meng
, Chunju Li

^*Corresponding author for this work

School of Physics and Electronic Science

Shanghai University
East China Normal University
Beijing Institute of Pharmacology and Toxicology

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Encapsulation of a physiologically active substance, sanguinarine (SA), by a water soluble carboxylatopillar[6]arene (CP6A), is described. The efficient complexation by CP6A, giving a K_a value of (2.4 ± 0.3) × 10⁵ M^-1 in pH 7.4, served to increase the water solubility by 4.3-fold, cause a 2.02 shift in pK_a, and enhance the antibacterial activity of SA.

Original language	English
Pages (from-to)	7381-7384
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	53
DOIs	https://doi.org/10.1039/c7cc02799k
State	Published - 2017

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@article{a8c70a7b26714e288615819d80850a2c,

title = "Highly efficient complexation of sanguinarine alkaloid by carboxylatopillar[6]arene: PK a shift, increased solubility and enhanced antibacterial activity",

abstract = "Encapsulation of a physiologically active substance, sanguinarine (SA), by a water soluble carboxylatopillar[6]arene (CP6A), is described. The efficient complexation by CP6A, giving a Ka value of (2.4 ± 0.3) × 105 M-1 in pH 7.4, served to increase the water solubility by 4.3-fold, cause a 2.02 shift in pKa, and enhance the antibacterial activity of SA.",

author = "Guchuan Ping and Yiliang Wang and Lingyun Shen and Yuting Wang and Xiaoshi Hu and Junyi Chen and Bingwen Hu and Lei Cui and Qingbin Meng and Chunju Li",

note = "Publisher Copyright: {\textcopyright} 2017 The Royal Society of Chemistry.",

year = "2017",

doi = "10.1039/c7cc02799k",

language = "英语",

volume = "53",

pages = "7381--7384",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "53",

}

TY - JOUR

T1 - Highly efficient complexation of sanguinarine alkaloid by carboxylatopillar[6]arene

T2 - PK a shift, increased solubility and enhanced antibacterial activity

AU - Ping, Guchuan

AU - Wang, Yiliang

AU - Shen, Lingyun

AU - Wang, Yuting

AU - Hu, Xiaoshi

AU - Chen, Junyi

AU - Hu, Bingwen

AU - Cui, Lei

AU - Meng, Qingbin

AU - Li, Chunju

PY - 2017

Y1 - 2017

N2 - Encapsulation of a physiologically active substance, sanguinarine (SA), by a water soluble carboxylatopillar[6]arene (CP6A), is described. The efficient complexation by CP6A, giving a Ka value of (2.4 ± 0.3) × 105 M-1 in pH 7.4, served to increase the water solubility by 4.3-fold, cause a 2.02 shift in pKa, and enhance the antibacterial activity of SA.

AB - Encapsulation of a physiologically active substance, sanguinarine (SA), by a water soluble carboxylatopillar[6]arene (CP6A), is described. The efficient complexation by CP6A, giving a Ka value of (2.4 ± 0.3) × 105 M-1 in pH 7.4, served to increase the water solubility by 4.3-fold, cause a 2.02 shift in pKa, and enhance the antibacterial activity of SA.

UR - https://www.scopus.com/pages/publications/85021689487

U2 - 10.1039/c7cc02799k

DO - 10.1039/c7cc02799k

M3 - 文章

C2 - 28613312

AN - SCOPUS:85021689487

SN - 1359-7345

VL - 53

SP - 7381

EP - 7384

JO - Chemical Communications

JF - Chemical Communications

IS - 53

ER -

Highly efficient complexation of sanguinarine alkaloid by carboxylatopillar[6]arene: PK _a shift, increased solubility and enhanced antibacterial activity

Abstract

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