Highly efficient antitumor agents of heterocycles containing sulfur atom: Linear and angular thiazonaphthalimides against human lung cancer cell in vitro

Xuhong Qian; Zhigang Li; Qing Yang

doi:10.1016/j.bmc.2007.07.008

Highly efficient antitumor agents of heterocycles containing sulfur atom: Linear and angular thiazonaphthalimides against human lung cancer cell in vitro

Xuhong Qian^*
, Zhigang Li
, Qing Yang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

A novel series of aminothiazonaphthalimides, A_1-2 and B_1-2, has been regioselectively synthesized. The linear compounds B_1-2 were evaluated to be far more active than their angular isomers A_1-2 in antitumor evaluation. The linear compounds C-F, derived from compound B₁, all showed highly efficient antitumor activities against A549 and P388 cell lines. Also, cytotoxicities of these four analogues against two tumor cells were highly dependent on the length of the side chains. The compound A₁ or B₁, with two methylene units in the side chain, was more cytotoxic than its corresponding homologue A₂ or B₂, with one more methylene unit.

Original language	English
Pages (from-to)	6846-6851
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry
Volume	15
Issue number	21
DOIs	https://doi.org/10.1016/j.bmc.2007.07.008
State	Published - 1 Nov 2007
Externally published	Yes

Keywords

Antitumor
DNA
Heterocycle
Intercalation
Naphthalimide
Photocleaver
Sulfur
Thiazole

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmc.2007.07.008

Cite this

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title = "Highly efficient antitumor agents of heterocycles containing sulfur atom: Linear and angular thiazonaphthalimides against human lung cancer cell in vitro",

abstract = "A novel series of aminothiazonaphthalimides, A1-2 and B1-2, has been regioselectively synthesized. The linear compounds B1-2 were evaluated to be far more active than their angular isomers A1-2 in antitumor evaluation. The linear compounds C-F, derived from compound B1, all showed highly efficient antitumor activities against A549 and P388 cell lines. Also, cytotoxicities of these four analogues against two tumor cells were highly dependent on the length of the side chains. The compound A1 or B1, with two methylene units in the side chain, was more cytotoxic than its corresponding homologue A2 or B2, with one more methylene unit.",

keywords = "Antitumor, DNA, Heterocycle, Intercalation, Naphthalimide, Photocleaver, Sulfur, Thiazole",

author = "Xuhong Qian and Zhigang Li and Qing Yang",

year = "2007",

month = nov,

day = "1",

doi = "10.1016/j.bmc.2007.07.008",

language = "英语",

volume = "15",

pages = "6846--6851",

journal = "Bioorganic and Medicinal Chemistry",

issn = "0968-0896",

publisher = "Elsevier Ltd",

number = "21",

}

TY - JOUR

T1 - Highly efficient antitumor agents of heterocycles containing sulfur atom

T2 - Linear and angular thiazonaphthalimides against human lung cancer cell in vitro

AU - Qian, Xuhong

AU - Li, Zhigang

AU - Yang, Qing

PY - 2007/11/1

Y1 - 2007/11/1

N2 - A novel series of aminothiazonaphthalimides, A1-2 and B1-2, has been regioselectively synthesized. The linear compounds B1-2 were evaluated to be far more active than their angular isomers A1-2 in antitumor evaluation. The linear compounds C-F, derived from compound B1, all showed highly efficient antitumor activities against A549 and P388 cell lines. Also, cytotoxicities of these four analogues against two tumor cells were highly dependent on the length of the side chains. The compound A1 or B1, with two methylene units in the side chain, was more cytotoxic than its corresponding homologue A2 or B2, with one more methylene unit.

AB - A novel series of aminothiazonaphthalimides, A1-2 and B1-2, has been regioselectively synthesized. The linear compounds B1-2 were evaluated to be far more active than their angular isomers A1-2 in antitumor evaluation. The linear compounds C-F, derived from compound B1, all showed highly efficient antitumor activities against A549 and P388 cell lines. Also, cytotoxicities of these four analogues against two tumor cells were highly dependent on the length of the side chains. The compound A1 or B1, with two methylene units in the side chain, was more cytotoxic than its corresponding homologue A2 or B2, with one more methylene unit.

KW - Antitumor

KW - DNA

KW - Heterocycle

KW - Intercalation

KW - Naphthalimide

KW - Photocleaver

KW - Sulfur

KW - Thiazole

UR - https://www.scopus.com/pages/publications/34548540642

U2 - 10.1016/j.bmc.2007.07.008

DO - 10.1016/j.bmc.2007.07.008

M3 - 文章

C2 - 17707644

AN - SCOPUS:34548540642

SN - 0968-0896

VL - 15

SP - 6846

EP - 6851

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

IS - 21

ER -

Highly efficient antitumor agents of heterocycles containing sulfur atom: Linear and angular thiazonaphthalimides against human lung cancer cell in vitro

Abstract

Keywords

UN SDGs

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