Highly diastereoselective synthesis of 3-hydroxy-2,2,3-trisubstituted indolines via intramolecular trapping of ammonium ylides with ketones

Changcheng Jing; Dong Xing; Wenhao Hu

doi:10.1039/c3cc48067d

Highly diastereoselective synthesis of 3-hydroxy-2,2,3-trisubstituted indolines via intramolecular trapping of ammonium ylides with ketones

Changcheng Jing
, Dong Xing
, Wenhao Hu^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

East China Normal University

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

A Rh₂(OAc)₄-catalyzed diazo decomposition reaction of diazo esters with 2-aminophenyl ketones is reported. A series of 3-hydroxy-2,2,3-trisubstituted indolines are produced in good yields with excellent diastereoselectivities via an intramolecular aldol-type trapping of ammonium ylides with ketone units.

Original language	English
Pages (from-to)	951-953
Number of pages	3
Journal	Chemical Communications
Volume	50
Issue number	8
DOIs	https://doi.org/10.1039/c3cc48067d
State	Published - 19 Dec 2014

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title = "Highly diastereoselective synthesis of 3-hydroxy-2,2,3-trisubstituted indolines via intramolecular trapping of ammonium ylides with ketones",

abstract = "A Rh2(OAc)4-catalyzed diazo decomposition reaction of diazo esters with 2-aminophenyl ketones is reported. A series of 3-hydroxy-2,2,3-trisubstituted indolines are produced in good yields with excellent diastereoselectivities via an intramolecular aldol-type trapping of ammonium ylides with ketone units.",

author = "Changcheng Jing and Dong Xing and Wenhao Hu",

year = "2014",

month = dec,

day = "19",

doi = "10.1039/c3cc48067d",

language = "英语",

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pages = "951--953",

journal = "Chemical Communications",

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T1 - Highly diastereoselective synthesis of 3-hydroxy-2,2,3-trisubstituted indolines via intramolecular trapping of ammonium ylides with ketones

AU - Jing, Changcheng

AU - Xing, Dong

AU - Hu, Wenhao

PY - 2014/12/19

Y1 - 2014/12/19

N2 - A Rh2(OAc)4-catalyzed diazo decomposition reaction of diazo esters with 2-aminophenyl ketones is reported. A series of 3-hydroxy-2,2,3-trisubstituted indolines are produced in good yields with excellent diastereoselectivities via an intramolecular aldol-type trapping of ammonium ylides with ketone units.

AB - A Rh2(OAc)4-catalyzed diazo decomposition reaction of diazo esters with 2-aminophenyl ketones is reported. A series of 3-hydroxy-2,2,3-trisubstituted indolines are produced in good yields with excellent diastereoselectivities via an intramolecular aldol-type trapping of ammonium ylides with ketone units.

UR - https://www.scopus.com/pages/publications/84890854942

U2 - 10.1039/c3cc48067d

DO - 10.1039/c3cc48067d

M3 - 文章

C2 - 24302029

AN - SCOPUS:84890854942

SN - 1359-7345

VL - 50

SP - 951

EP - 953

JO - Chemical Communications

JF - Chemical Communications

IS - 8

ER -

Highly diastereoselective synthesis of 3-hydroxy-2,2,3-trisubstituted indolines via intramolecular trapping of ammonium ylides with ketones

Abstract

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