Abstract
Trapped: A Michael-aldol-type cascade reaction including the trapping of an oxonium ylide through a delayed proton shift leads to the formation of multiple stereocenters in a mild one-pot synthesis. Enantiomerically pure indanol derivatives with four stereocenters and a stereogenic quaternary carbon center were easily obtained through this method in moderate to good yields.
| Original language | English |
|---|---|
| Pages (from-to) | 1539-1542 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 52 |
| Issue number | 5 |
| DOIs | |
| State | Published - 28 Jan 2013 |
Keywords
- cascade reactions
- diastereoselectivity
- multicomponent reactions
- oxonium ylides
- stereogenic centers
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