Abstract
Objective: To provide fundamental data for developing an effective immunization strategy by different types of recombinant vaccines to protect HIV-2 infection. Methods: Using prime-boost immunizations strategy, BALB/c mice were inoculated muscularly with HIV-2 gp105 recombinant DNA vaccine and fowlpox virus. The numbers of CD4+ and CD8+ subgroup of spleen T lymphocyte, the specific killing activities of spleen CTL and the titers of serum antibodies of the immunized mice were detected. Results: HIV-2 specific target-killing activity of spleen CTL and serum HIV-2 specific antibody level were higher in combined immunization group than those in single immunization groups (P<0.05). Conclusion: The stra tegy of prime-boost may stimulate stronger specific celluar and humoral immune responses in mice.
| Original language | English |
|---|---|
| Pages (from-to) | 1-3 |
| Number of pages | 3 |
| Journal | Journal of Jilin University Medicine Edition |
| Volume | 32 |
| Issue number | 1 |
| State | Published - 28 Jan 2006 |
Keywords
- DNA
- HIV-2
- Immunization strategy
- Prime-boost
- Recobinant fowlpox virus
- Vaccines
- gp105
