High-Order Mid-Infrared Nonlinear Topological Differentiator

High-order edge-enhanced imaging enables precise feature localization and effective background suppression, offering a powerful tool for real-time recognition and high-contrast visualization. Extending this capability to the mid-infrared (MIR) regime is particularly valuable for applications such as biomedical diagnostics, material inspection, and remote sensing, yet remains limited by inadequate spatial-frequency modulation fidelity and low detection sensitivity. Here, we demonstrate a high-sensitivity MIR upconversion differentiator operating at 3 (Formula presented.), which achieves isotropic high-order edge enhancement by optically imprinting topological complex-amplitude patterns onto MIR Fourier components via nonlinear parametric interaction. Vortex transfer functions (Formula presented.) are precisely encoded on a phase-only spatial light modulator to enable tunable MIR differentiation from first- to fourth- order, with real-time switching at up to 60 Hz. Benefiting from a low-noise upconversion process and a single-photon-sensitive silicon camera, the system achieves high-contrast edge imaging under low-light conditions. Experimental results confirm accurate edge extraction and background suppression for both amplitude and phase objects, hence underscoring its potential for noninvasive diagnostics and label-free material analysis.