Hemin-phytic Acid Functionalized Porous Conducting Polymer Hydrogel With Good Biocompatibility for Electrochemical Detection of H2O2 Released From Living Cells

Xin Shang; Shaoying He; Zhiai Xu; Wei Lu; Wen Zhang

doi:10.1002/elan.202060499

Hemin-phytic Acid Functionalized Porous Conducting Polymer Hydrogel With Good Biocompatibility for Electrochemical Detection of H₂O₂ Released From Living Cells

Xin Shang
, Shaoying He
, Zhiai Xu
, Wei Lu
, Wen Zhang^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

East China Normal University

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

A novel hemin/phytic acid doped polyaniline (PA-PANI) hydrogel composite was prepared through a simple chemical and self-assembly method, which was modified onto electrode for electrochemical detection of H₂O₂ released from living cells. It showed good analytical performance with high sensitivity, selectivity and a rapid response for the analysis of H₂O₂ in the range of 2 to 102 μM, with the detection limit of 1.2 μM. The favorable results mainly originated from both the high conductivity of PA-PANI hydrogel and its network structure preventing hemin from self-dimerization to provide active catalytic species. Furthermore, PA-PANI with good biocompatibility allowed living cells to adhere and resulted in a short diffusion distance between H₂O₂ released from cells and electrode.

Original language	English
Pages (from-to)	1088-1095
Number of pages	8
Journal	Electroanalysis
Volume	33
Issue number	4
DOIs	https://doi.org/10.1002/elan.202060499
State	Published - Apr 2021

Keywords

Cell
Electrochemical
Hemin
Hydrogen Peroxide
Polyaniline

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10.1002/elan.202060499

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@article{c399f0c193574c5eb95458164ba53219,

title = "Hemin-phytic Acid Functionalized Porous Conducting Polymer Hydrogel With Good Biocompatibility for Electrochemical Detection of H2O2 Released From Living Cells",

abstract = "A novel hemin/phytic acid doped polyaniline (PA-PANI) hydrogel composite was prepared through a simple chemical and self-assembly method, which was modified onto electrode for electrochemical detection of H2O2 released from living cells. It showed good analytical performance with high sensitivity, selectivity and a rapid response for the analysis of H2O2 in the range of 2 to 102 μM, with the detection limit of 1.2 μM. The favorable results mainly originated from both the high conductivity of PA-PANI hydrogel and its network structure preventing hemin from self-dimerization to provide active catalytic species. Furthermore, PA-PANI with good biocompatibility allowed living cells to adhere and resulted in a short diffusion distance between H2O2 released from cells and electrode.",

keywords = "Cell, Electrochemical, Hemin, Hydrogen Peroxide, Polyaniline",

author = "Xin Shang and Shaoying He and Zhiai Xu and Wei Lu and Wen Zhang",

note = "Publisher Copyright: {\textcopyright} 2021 Wiley-VCH GmbH",

year = "2021",

month = apr,

doi = "10.1002/elan.202060499",

language = "英语",

volume = "33",

pages = "1088--1095",

journal = "Electroanalysis",

issn = "1040-0397",

publisher = "Wiley-VCH Verlag",

number = "4",

}

TY - JOUR

T1 - Hemin-phytic Acid Functionalized Porous Conducting Polymer Hydrogel With Good Biocompatibility for Electrochemical Detection of H2O2 Released From Living Cells

AU - Shang, Xin

AU - He, Shaoying

AU - Xu, Zhiai

AU - Lu, Wei

AU - Zhang, Wen

PY - 2021/4

Y1 - 2021/4

N2 - A novel hemin/phytic acid doped polyaniline (PA-PANI) hydrogel composite was prepared through a simple chemical and self-assembly method, which was modified onto electrode for electrochemical detection of H2O2 released from living cells. It showed good analytical performance with high sensitivity, selectivity and a rapid response for the analysis of H2O2 in the range of 2 to 102 μM, with the detection limit of 1.2 μM. The favorable results mainly originated from both the high conductivity of PA-PANI hydrogel and its network structure preventing hemin from self-dimerization to provide active catalytic species. Furthermore, PA-PANI with good biocompatibility allowed living cells to adhere and resulted in a short diffusion distance between H2O2 released from cells and electrode.

AB - A novel hemin/phytic acid doped polyaniline (PA-PANI) hydrogel composite was prepared through a simple chemical and self-assembly method, which was modified onto electrode for electrochemical detection of H2O2 released from living cells. It showed good analytical performance with high sensitivity, selectivity and a rapid response for the analysis of H2O2 in the range of 2 to 102 μM, with the detection limit of 1.2 μM. The favorable results mainly originated from both the high conductivity of PA-PANI hydrogel and its network structure preventing hemin from self-dimerization to provide active catalytic species. Furthermore, PA-PANI with good biocompatibility allowed living cells to adhere and resulted in a short diffusion distance between H2O2 released from cells and electrode.

KW - Cell

KW - Electrochemical

KW - Hemin

KW - Hydrogen Peroxide

KW - Polyaniline

UR - https://www.scopus.com/pages/publications/85099028883

U2 - 10.1002/elan.202060499

DO - 10.1002/elan.202060499

M3 - 文章

AN - SCOPUS:85099028883

SN - 1040-0397

VL - 33

SP - 1088

EP - 1095

JO - Electroanalysis

JF - Electroanalysis

IS - 4

ER -

Hemin-phytic Acid Functionalized Porous Conducting Polymer Hydrogel With Good Biocompatibility for Electrochemical Detection of H₂O₂ Released From Living Cells

Abstract

Keywords

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