HDAC3: Taking the SMRT-N-CoRrect road to repression

P. Karagianni; J. Wong

doi:10.1038/sj.onc.1210612

HDAC3: Taking the SMRT-N-CoRrect road to repression

P. Karagianni
, J. Wong^*

^*Corresponding author for this work

School of Life Sciences

Baylor College of Medicine

Research output: Contribution to journal › Review article › peer-review

197 Scopus citations

Abstract

Known histone deacetylases (HDACs) are divided into different classes, and HDAC3 belongs to Class I. Through forming multiprotein complexes with the corepressors SMRT and N-CoR, HDAC3 regulates the transcription of a plethora of genes. A growing list of nonhistone substrates extends the role of HDAC3 beyond transcriptional repression. Here, we review data on the composition, regulation and mechanism of action of the SMRT/N-CoR-HDAC3 complexes and provide several examples of nontranscriptional functions, to illustrate the wide variety of physiological processes affected by this deacetylase. Furthermore, we discuss the implication of HDAC3 in cancer, focusing on leukemia. We conclude with some thoughts about the potential therapeutic efficacies of HDAC3 activity modulation.

Original language	English
Pages (from-to)	5439-5449
Number of pages	11
Journal	Oncogene
Volume	26
Issue number	37
DOIs	https://doi.org/10.1038/sj.onc.1210612
State	Published - 13 Aug 2007

Keywords

Corepressor complex
HDAC3
Histone deacetylation
N-CoR
Repression and cancer
SMRT

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/sj.onc.1210612

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title = "HDAC3: Taking the SMRT-N-CoRrect road to repression",

abstract = "Known histone deacetylases (HDACs) are divided into different classes, and HDAC3 belongs to Class I. Through forming multiprotein complexes with the corepressors SMRT and N-CoR, HDAC3 regulates the transcription of a plethora of genes. A growing list of nonhistone substrates extends the role of HDAC3 beyond transcriptional repression. Here, we review data on the composition, regulation and mechanism of action of the SMRT/N-CoR-HDAC3 complexes and provide several examples of nontranscriptional functions, to illustrate the wide variety of physiological processes affected by this deacetylase. Furthermore, we discuss the implication of HDAC3 in cancer, focusing on leukemia. We conclude with some thoughts about the potential therapeutic efficacies of HDAC3 activity modulation.",

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T1 - HDAC3

T2 - Taking the SMRT-N-CoRrect road to repression

AU - Karagianni, P.

AU - Wong, J.

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N2 - Known histone deacetylases (HDACs) are divided into different classes, and HDAC3 belongs to Class I. Through forming multiprotein complexes with the corepressors SMRT and N-CoR, HDAC3 regulates the transcription of a plethora of genes. A growing list of nonhistone substrates extends the role of HDAC3 beyond transcriptional repression. Here, we review data on the composition, regulation and mechanism of action of the SMRT/N-CoR-HDAC3 complexes and provide several examples of nontranscriptional functions, to illustrate the wide variety of physiological processes affected by this deacetylase. Furthermore, we discuss the implication of HDAC3 in cancer, focusing on leukemia. We conclude with some thoughts about the potential therapeutic efficacies of HDAC3 activity modulation.

AB - Known histone deacetylases (HDACs) are divided into different classes, and HDAC3 belongs to Class I. Through forming multiprotein complexes with the corepressors SMRT and N-CoR, HDAC3 regulates the transcription of a plethora of genes. A growing list of nonhistone substrates extends the role of HDAC3 beyond transcriptional repression. Here, we review data on the composition, regulation and mechanism of action of the SMRT/N-CoR-HDAC3 complexes and provide several examples of nontranscriptional functions, to illustrate the wide variety of physiological processes affected by this deacetylase. Furthermore, we discuss the implication of HDAC3 in cancer, focusing on leukemia. We conclude with some thoughts about the potential therapeutic efficacies of HDAC3 activity modulation.

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KW - HDAC3

KW - Histone deacetylation

KW - N-CoR

KW - Repression and cancer

KW - SMRT

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DO - 10.1038/sj.onc.1210612

M3 - 文献综述

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AN - SCOPUS:34547909260

SN - 0950-9232

VL - 26

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EP - 5449

JO - Oncogene

JF - Oncogene

IS - 37

ER -

HDAC3: Taking the SMRT-N-CoRrect road to repression

Abstract

Keywords

UN SDGs

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