Abstract
Michael addition and Aldol reaction are among the most basic and commoly used reactions. Cascade halo-Michael/Aldol reaction can effectively improve the atomic economy and step economy of organic synthesis. After the Michael addition of α, β-unsaturated compound with halide ion (Cl-, Br-, I-), the reactive intermediate reacts with aldehyde through Aldol reaction in the same reaction system, this process called cascade halo-Michael/Aldol reaction. This review will introduce the cascade halo-Michael/Aldol reaction and its applications in the synthesis of related compounds according to the types of Lewis Acid.
| Translated title of the contribution | Cascade halo-Michael/Aldol Reaction and Its Application in Synthesis |
|---|---|
| Original language | Chinese (Traditional) |
| Pages (from-to) | 1608-1625 |
| Number of pages | 18 |
| Journal | Chinese Journal of Organic Chemistry |
| Volume | 38 |
| Issue number | 7 |
| DOIs | |
| State | Published - 1 Jul 2018 |