Growth and inhibition of monohydrate sodium urate banded spherulites

Yao Zhou; Xiaowei Feng; Ting Wang; Yang Tian; Xiaoyan Cui

doi:10.1039/d0ce01378a

Growth and inhibition of monohydrate sodium urate banded spherulites

Yao Zhou
, Xiaowei Feng
, Ting Wang
, Yang Tian
, Xiaoyan Cui^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Gout is a chronic arthritis which arises from the abnormal crystalline deposition of monosodium urate (MSU). Banded spherulites of MSU were widely observed in gout pathological slices (E. Pascual, L. Addadi, M. Andrés and F. Sivera,Nat. Rev. Rheumatol., 2015, 11, 725) with limited understanding. MSU spherulites were obtained by evaporation growth showing banded morphologies induced from both twisting and rhythmic deposition. Taking the MSU spherulite as a facile model for the analysis of inhibitors for MSU crystals, the inhibition of MSU by three tailor-made additives, 1,3-dimethyluric acid (DMUA), 1-methyluric acid (MUA), and xanthine, resulted in MSU spherulites with different morphologies. The theoretical calculation has confirmed the distinct interaction of the different additives on the MSU crystalline faces.

Original language	English
Pages (from-to)	1439-1446
Number of pages	8
Journal	CrystEngComm
Volume	23
Issue number	6
DOIs	https://doi.org/10.1039/d0ce01378a
State	Published - 14 Feb 2021

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title = "Growth and inhibition of monohydrate sodium urate banded spherulites",

abstract = "Gout is a chronic arthritis which arises from the abnormal crystalline deposition of monosodium urate (MSU). Banded spherulites of MSU were widely observed in gout pathological slices (E. Pascual, L. Addadi, M. Andr{\'e}s and F. Sivera,Nat. Rev. Rheumatol., 2015, 11, 725) with limited understanding. MSU spherulites were obtained by evaporation growth showing banded morphologies induced from both twisting and rhythmic deposition. Taking the MSU spherulite as a facile model for the analysis of inhibitors for MSU crystals, the inhibition of MSU by three tailor-made additives, 1,3-dimethyluric acid (DMUA), 1-methyluric acid (MUA), and xanthine, resulted in MSU spherulites with different morphologies. The theoretical calculation has confirmed the distinct interaction of the different additives on the MSU crystalline faces.",

author = "Yao Zhou and Xiaowei Feng and Ting Wang and Yang Tian and Xiaoyan Cui",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2021.",

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doi = "10.1039/d0ce01378a",

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T1 - Growth and inhibition of monohydrate sodium urate banded spherulites

AU - Zhou, Yao

AU - Feng, Xiaowei

AU - Wang, Ting

AU - Tian, Yang

AU - Cui, Xiaoyan

PY - 2021/2/14

Y1 - 2021/2/14

N2 - Gout is a chronic arthritis which arises from the abnormal crystalline deposition of monosodium urate (MSU). Banded spherulites of MSU were widely observed in gout pathological slices (E. Pascual, L. Addadi, M. Andrés and F. Sivera,Nat. Rev. Rheumatol., 2015, 11, 725) with limited understanding. MSU spherulites were obtained by evaporation growth showing banded morphologies induced from both twisting and rhythmic deposition. Taking the MSU spherulite as a facile model for the analysis of inhibitors for MSU crystals, the inhibition of MSU by three tailor-made additives, 1,3-dimethyluric acid (DMUA), 1-methyluric acid (MUA), and xanthine, resulted in MSU spherulites with different morphologies. The theoretical calculation has confirmed the distinct interaction of the different additives on the MSU crystalline faces.

AB - Gout is a chronic arthritis which arises from the abnormal crystalline deposition of monosodium urate (MSU). Banded spherulites of MSU were widely observed in gout pathological slices (E. Pascual, L. Addadi, M. Andrés and F. Sivera,Nat. Rev. Rheumatol., 2015, 11, 725) with limited understanding. MSU spherulites were obtained by evaporation growth showing banded morphologies induced from both twisting and rhythmic deposition. Taking the MSU spherulite as a facile model for the analysis of inhibitors for MSU crystals, the inhibition of MSU by three tailor-made additives, 1,3-dimethyluric acid (DMUA), 1-methyluric acid (MUA), and xanthine, resulted in MSU spherulites with different morphologies. The theoretical calculation has confirmed the distinct interaction of the different additives on the MSU crystalline faces.

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U2 - 10.1039/d0ce01378a

DO - 10.1039/d0ce01378a

M3 - 文章

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SN - 1466-8033

VL - 23

SP - 1439

EP - 1446

JO - CrystEngComm

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IS - 6

ER -

Growth and inhibition of monohydrate sodium urate banded spherulites

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