Growth and Biological Interactions of Uric Acid Crystals Tracked by Heteroatom-Substituted Rhodamines

Nichang Xue; Mengyuan Hao; Yue Tian; Yao Zhou; Hanzhang Chen; Ting Wang; Xiaoyan Cui; Yang Tian

doi:10.1021/acs.cgd.4c00471

Growth and Biological Interactions of Uric Acid Crystals Tracked by Heteroatom-Substituted Rhodamines

Nichang Xue
, Mengyuan Hao
, Yue Tian
, Yao Zhou
, Hanzhang Chen
, Ting Wang^*
, Xiaoyan Cui^*
, Yang Tian^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

East China Normal University
Tongji University
Shanghai Engineering Research Center of Topical Chinese Medicine

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The formation of pathological crystals is the origin of many diseases, although the growth mechanisms, crystalline formations, interactions with cells, and intracellular activities of the crystals are still poorly understood. Uric acid (UA) crystals, one of the essential components of kidney stones, are explored by the selective recognition of heteroatom-substituted rhodamines (HSRs). Moreover, the highly specific interaction between HSRs and UA crystals was also confirmed by the tuned growth of uric acid banded spherulites. With the HSR-dyed UA crystals, we sensitively tracked the stepwise interaction of crystals and live cells from the adhesive, internalization of crystals, and lysosome-involved inflammation in vivo.

Original language	English
Pages (from-to)	10073-10081
Number of pages	9
Journal	Crystal Growth and Design
Volume	24
Issue number	24
DOIs	https://doi.org/10.1021/acs.cgd.4c00471
State	Published - 18 Dec 2024

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abstract = "The formation of pathological crystals is the origin of many diseases, although the growth mechanisms, crystalline formations, interactions with cells, and intracellular activities of the crystals are still poorly understood. Uric acid (UA) crystals, one of the essential components of kidney stones, are explored by the selective recognition of heteroatom-substituted rhodamines (HSRs). Moreover, the highly specific interaction between HSRs and UA crystals was also confirmed by the tuned growth of uric acid banded spherulites. With the HSR-dyed UA crystals, we sensitively tracked the stepwise interaction of crystals and live cells from the adhesive, internalization of crystals, and lysosome-involved inflammation in vivo.",

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T1 - Growth and Biological Interactions of Uric Acid Crystals Tracked by Heteroatom-Substituted Rhodamines

AU - Xue, Nichang

AU - Hao, Mengyuan

AU - Tian, Yue

AU - Zhou, Yao

AU - Chen, Hanzhang

AU - Wang, Ting

AU - Cui, Xiaoyan

AU - Tian, Yang

PY - 2024/12/18

Y1 - 2024/12/18

N2 - The formation of pathological crystals is the origin of many diseases, although the growth mechanisms, crystalline formations, interactions with cells, and intracellular activities of the crystals are still poorly understood. Uric acid (UA) crystals, one of the essential components of kidney stones, are explored by the selective recognition of heteroatom-substituted rhodamines (HSRs). Moreover, the highly specific interaction between HSRs and UA crystals was also confirmed by the tuned growth of uric acid banded spherulites. With the HSR-dyed UA crystals, we sensitively tracked the stepwise interaction of crystals and live cells from the adhesive, internalization of crystals, and lysosome-involved inflammation in vivo.

AB - The formation of pathological crystals is the origin of many diseases, although the growth mechanisms, crystalline formations, interactions with cells, and intracellular activities of the crystals are still poorly understood. Uric acid (UA) crystals, one of the essential components of kidney stones, are explored by the selective recognition of heteroatom-substituted rhodamines (HSRs). Moreover, the highly specific interaction between HSRs and UA crystals was also confirmed by the tuned growth of uric acid banded spherulites. With the HSR-dyed UA crystals, we sensitively tracked the stepwise interaction of crystals and live cells from the adhesive, internalization of crystals, and lysosome-involved inflammation in vivo.

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DO - 10.1021/acs.cgd.4c00471

M3 - 文章

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SN - 1528-7483

VL - 24

SP - 10073

EP - 10081

JO - Crystal Growth and Design

JF - Crystal Growth and Design

IS - 24

ER -

Growth and Biological Interactions of Uric Acid Crystals Tracked by Heteroatom-Substituted Rhodamines

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