Gram-Scale Synthesis of Sulfoxides via Oxygen Enabled by Fe(NO3)3·9H2O

Kai Liu; Jiaolong Meng; Xuefeng Jiang

doi:10.1021/acs.oprd.2c00390

Gram-Scale Synthesis of Sulfoxides via Oxygen Enabled by Fe(NO₃)₃·9H₂O

Kai Liu
, Jiaolong Meng
, Xuefeng Jiang^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

Research output: Contribution to journal › Review article › peer-review

36 Scopus citations

Abstract

Sulfoxides, as an essential pivot, are commonly found in pharmaceuticals and bulk chemicals. A practical synthetic protocol is depicted via application of readily obtainable Fe(NO₃)₃·9H₂O as a catalyst and oxygen as a green oxidant for selective oxidation from thioethers to sulfoxides under ecofriendly and mild conditions. Various sulfoxides are all achieved in gram-scale with superior selectivity and efficiency. This protocol showcases broad-spectrum functional group compatibility, offering efficient access to sulfoxide construction for drug discovery and process optimization.

Original language	English
Pages (from-to)	1198-1202
Number of pages	5
Journal	Organic Process Research and Development
Volume	27
Issue number	7
DOIs	https://doi.org/10.1021/acs.oprd.2c00390
State	Published - 21 Jul 2023

Keywords

Fe(NO)·9HO
gram-scale
oxidization
sulfoxide

Access to Document

10.1021/acs.oprd.2c00390

Cite this

@article{e3842de627ba47b296e665b59b3a271a,

title = "Gram-Scale Synthesis of Sulfoxides via Oxygen Enabled by Fe(NO3)3·9H2O",

abstract = "Sulfoxides, as an essential pivot, are commonly found in pharmaceuticals and bulk chemicals. A practical synthetic protocol is depicted via application of readily obtainable Fe(NO3)3·9H2O as a catalyst and oxygen as a green oxidant for selective oxidation from thioethers to sulfoxides under ecofriendly and mild conditions. Various sulfoxides are all achieved in gram-scale with superior selectivity and efficiency. This protocol showcases broad-spectrum functional group compatibility, offering efficient access to sulfoxide construction for drug discovery and process optimization.",

keywords = "Fe(NO)·9HO, gram-scale, oxidization, sulfoxide",

author = "Kai Liu and Jiaolong Meng and Xuefeng Jiang",

note = "Publisher Copyright: {\textcopyright} 2023 American Chemical Society",

year = "2023",

month = jul,

day = "21",

doi = "10.1021/acs.oprd.2c00390",

language = "英语",

volume = "27",

pages = "1198--1202",

journal = "Organic Process Research and Development",

issn = "1083-6160",

publisher = "American Chemical Society",

number = "7",

}

TY - JOUR

T1 - Gram-Scale Synthesis of Sulfoxides via Oxygen Enabled by Fe(NO3)3·9H2O

AU - Liu, Kai

AU - Meng, Jiaolong

AU - Jiang, Xuefeng

PY - 2023/7/21

Y1 - 2023/7/21

N2 - Sulfoxides, as an essential pivot, are commonly found in pharmaceuticals and bulk chemicals. A practical synthetic protocol is depicted via application of readily obtainable Fe(NO3)3·9H2O as a catalyst and oxygen as a green oxidant for selective oxidation from thioethers to sulfoxides under ecofriendly and mild conditions. Various sulfoxides are all achieved in gram-scale with superior selectivity and efficiency. This protocol showcases broad-spectrum functional group compatibility, offering efficient access to sulfoxide construction for drug discovery and process optimization.

AB - Sulfoxides, as an essential pivot, are commonly found in pharmaceuticals and bulk chemicals. A practical synthetic protocol is depicted via application of readily obtainable Fe(NO3)3·9H2O as a catalyst and oxygen as a green oxidant for selective oxidation from thioethers to sulfoxides under ecofriendly and mild conditions. Various sulfoxides are all achieved in gram-scale with superior selectivity and efficiency. This protocol showcases broad-spectrum functional group compatibility, offering efficient access to sulfoxide construction for drug discovery and process optimization.

KW - Fe(NO)·9HO

KW - gram-scale

KW - oxidization

KW - sulfoxide

UR - https://www.scopus.com/pages/publications/85148029931

U2 - 10.1021/acs.oprd.2c00390

DO - 10.1021/acs.oprd.2c00390

M3 - 文献综述

AN - SCOPUS:85148029931

SN - 1083-6160

VL - 27

SP - 1198

EP - 1202

JO - Organic Process Research and Development

JF - Organic Process Research and Development

IS - 7

ER -

Gram-Scale Synthesis of Sulfoxides via Oxygen Enabled by Fe(NO₃)₃·9H₂O

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this