Gold-catalyzed intermolecular [4+1] spiroannulation: via site-selective aromatic C(sp2)-H functionalization and dearomatization of phenol derivatives

Yongfeng Li; Zhiqiong Tang; Junliang Zhang; Lu Liu

doi:10.1039/d0cc01118e

Gold-catalyzed intermolecular [4+1] spiroannulation: via site-selective aromatic C(sp²)-H functionalization and dearomatization of phenol derivatives

Yongfeng Li
, Zhiqiong Tang
, Junliang Zhang
, Lu Liu

School of Chemistry and Molecular Engineering

East China Normal University
Fudan University

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Herein, we have developed a novel and simple protocol to realize the C-H bond functionalization/dearomatization of naphthols and phenols with ortho-alkynylaryl-α-diazoesters under gold(i) catalysis. In this protocol, various spirocyclic molecules could be obtained in good yields with excellent chemo- and regio-selectivity and moderate to good diastereoselectivity.

Original language	English
Pages (from-to)	8202-8205
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	59
DOIs	https://doi.org/10.1039/d0cc01118e
State	Published - 28 Jul 2020

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10.1039/d0cc01118e

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title = "Gold-catalyzed intermolecular [4+1] spiroannulation: via site-selective aromatic C(sp2)-H functionalization and dearomatization of phenol derivatives",

abstract = "Herein, we have developed a novel and simple protocol to realize the C-H bond functionalization/dearomatization of naphthols and phenols with ortho-alkynylaryl-α-diazoesters under gold(i) catalysis. In this protocol, various spirocyclic molecules could be obtained in good yields with excellent chemo- and regio-selectivity and moderate to good diastereoselectivity.",

author = "Yongfeng Li and Zhiqiong Tang and Junliang Zhang and Lu Liu",

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AU - Li, Yongfeng

AU - Tang, Zhiqiong

AU - Zhang, Junliang

AU - Liu, Lu

PY - 2020/7/28

Y1 - 2020/7/28

N2 - Herein, we have developed a novel and simple protocol to realize the C-H bond functionalization/dearomatization of naphthols and phenols with ortho-alkynylaryl-α-diazoesters under gold(i) catalysis. In this protocol, various spirocyclic molecules could be obtained in good yields with excellent chemo- and regio-selectivity and moderate to good diastereoselectivity.

AB - Herein, we have developed a novel and simple protocol to realize the C-H bond functionalization/dearomatization of naphthols and phenols with ortho-alkynylaryl-α-diazoesters under gold(i) catalysis. In this protocol, various spirocyclic molecules could be obtained in good yields with excellent chemo- and regio-selectivity and moderate to good diastereoselectivity.

UR - https://www.scopus.com/pages/publications/85088608585

U2 - 10.1039/d0cc01118e

DO - 10.1039/d0cc01118e

M3 - 文章

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AN - SCOPUS:85088608585

SN - 1359-7345

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JO - Chemical Communications

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ER -

Gold-catalyzed intermolecular [4+1] spiroannulation: via site-selective aromatic C(sp²)-H functionalization and dearomatization of phenol derivatives

Abstract

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