TY - JOUR
T1 - Genomic expression profiles in liver of mice exposed to purified terephthalic acid manufacturing wastewater
AU - Zhang, Zongyao
AU - Ma, Liping
AU - Zhang, Xu Xiang
AU - Li, Weixin
AU - Zhang, Yan
AU - Wu, Bing
AU - Yang, Liuyan
AU - Cheng, Shupei
PY - 2010/9
Y1 - 2010/9
N2 - DNA micorarray was used to analyze hepatic transcriptional profile of male mice (Mus musculus) after 35-d intragastric perfusion treatment with purified terephthalic acid (PTA) manufacturing wastewater. Haematological analysis demonstrated that the levels of glutamyl transferase and lactate dehydrogenase in serum were significantly decreased, and DNA microarray showed that a total of 306 genes were differentially expressed in PTA wastewater-treated mice. According to Kyoto encyclopedia of genes and genomes pathway database, the differentially expressed genes were mainly grouped to metabolic pathways (58 genes) and biological processes (101 genes). PTA wastewater had significant impacts upon metabolisms of lipid, carbohydrate, amino acid, vitamin and nucleotide. Several signal transduction pathways are most susceptible to PTA wastewater, including mitogen-activated protein kinases, Janus kinase/signal transducers and activators of transcription and calcium signaling pathways. Potential public health problems may arise from the discharge of PTA wastewater into the environment.
AB - DNA micorarray was used to analyze hepatic transcriptional profile of male mice (Mus musculus) after 35-d intragastric perfusion treatment with purified terephthalic acid (PTA) manufacturing wastewater. Haematological analysis demonstrated that the levels of glutamyl transferase and lactate dehydrogenase in serum were significantly decreased, and DNA microarray showed that a total of 306 genes were differentially expressed in PTA wastewater-treated mice. According to Kyoto encyclopedia of genes and genomes pathway database, the differentially expressed genes were mainly grouped to metabolic pathways (58 genes) and biological processes (101 genes). PTA wastewater had significant impacts upon metabolisms of lipid, carbohydrate, amino acid, vitamin and nucleotide. Several signal transduction pathways are most susceptible to PTA wastewater, including mitogen-activated protein kinases, Janus kinase/signal transducers and activators of transcription and calcium signaling pathways. Potential public health problems may arise from the discharge of PTA wastewater into the environment.
KW - Genomic toxicity
KW - Industrial wastewater
KW - Microarray
KW - Purified terephthalic acid
UR - https://www.scopus.com/pages/publications/77954538002
U2 - 10.1016/j.jhazmat.2010.05.131
DO - 10.1016/j.jhazmat.2010.05.131
M3 - 文章
C2 - 20566238
AN - SCOPUS:77954538002
SN - 0304-3894
VL - 181
SP - 1121
EP - 1126
JO - Journal of Hazardous Materials
JF - Journal of Hazardous Materials
IS - 1-3
ER -
