Abstract
DNA micorarray was used to analyze hepatic transcriptional profile of male mice (Mus musculus) after 35-d intragastric perfusion treatment with purified terephthalic acid (PTA) manufacturing wastewater. Haematological analysis demonstrated that the levels of glutamyl transferase and lactate dehydrogenase in serum were significantly decreased, and DNA microarray showed that a total of 306 genes were differentially expressed in PTA wastewater-treated mice. According to Kyoto encyclopedia of genes and genomes pathway database, the differentially expressed genes were mainly grouped to metabolic pathways (58 genes) and biological processes (101 genes). PTA wastewater had significant impacts upon metabolisms of lipid, carbohydrate, amino acid, vitamin and nucleotide. Several signal transduction pathways are most susceptible to PTA wastewater, including mitogen-activated protein kinases, Janus kinase/signal transducers and activators of transcription and calcium signaling pathways. Potential public health problems may arise from the discharge of PTA wastewater into the environment.
| Original language | English |
|---|---|
| Pages (from-to) | 1121-1126 |
| Number of pages | 6 |
| Journal | Journal of Hazardous Materials |
| Volume | 181 |
| Issue number | 1-3 |
| DOIs | |
| State | Published - Sep 2010 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
-
SDG 3 Good Health and Well-being
Keywords
- Genomic toxicity
- Industrial wastewater
- Microarray
- Purified terephthalic acid
Fingerprint
Dive into the research topics of 'Genomic expression profiles in liver of mice exposed to purified terephthalic acid manufacturing wastewater'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver