G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders

Thian Sze Wong; Guangzhi Li; Shiliang Li; Wei Gao; Geng Chen; Shiyi Gan; Manzhan Zhang; Honglin Li; Song Wu; Yang Du

doi:10.1038/s41392-023-01427-2

G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders

Thian Sze Wong
, Guangzhi Li
, Shiliang Li
, Wei Gao
, Geng Chen
, Shiyi Gan
, Manzhan Zhang
, Honglin Li^*
, Song Wu^*
, Yang Du^*

^*Corresponding author for this work

School of Pharmaceutical Sciences

Research output: Contribution to journal › Review article › peer-review

99 Scopus citations

Abstract

Neuropsychiatric disorders are multifactorial disorders with diverse aetiological factors. Identifying treatment targets is challenging because the diseases are resulting from heterogeneous biological, genetic, and environmental factors. Nevertheless, the increasing understanding of G protein-coupled receptor (GPCR) opens a new possibility in drug discovery. Harnessing our knowledge of molecular mechanisms and structural information of GPCRs will be advantageous for developing effective drugs. This review provides an overview of the role of GPCRs in various neurodegenerative and psychiatric diseases. Besides, we highlight the emerging opportunities of novel GPCR targets and address recent progress in GPCR drug development.

Original language	English
Article number	177
Journal	Signal Transduction and Targeted Therapy
Volume	8
Issue number	1
DOIs	https://doi.org/10.1038/s41392-023-01427-2
State	Published - Dec 2023

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title = "G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders",

abstract = "Neuropsychiatric disorders are multifactorial disorders with diverse aetiological factors. Identifying treatment targets is challenging because the diseases are resulting from heterogeneous biological, genetic, and environmental factors. Nevertheless, the increasing understanding of G protein-coupled receptor (GPCR) opens a new possibility in drug discovery. Harnessing our knowledge of molecular mechanisms and structural information of GPCRs will be advantageous for developing effective drugs. This review provides an overview of the role of GPCRs in various neurodegenerative and psychiatric diseases. Besides, we highlight the emerging opportunities of novel GPCR targets and address recent progress in GPCR drug development.",

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T1 - G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders

AU - Wong, Thian Sze

AU - Li, Guangzhi

AU - Li, Shiliang

AU - Gao, Wei

AU - Chen, Geng

AU - Gan, Shiyi

AU - Zhang, Manzhan

AU - Li, Honglin

AU - Wu, Song

AU - Du, Yang

PY - 2023/12

Y1 - 2023/12

N2 - Neuropsychiatric disorders are multifactorial disorders with diverse aetiological factors. Identifying treatment targets is challenging because the diseases are resulting from heterogeneous biological, genetic, and environmental factors. Nevertheless, the increasing understanding of G protein-coupled receptor (GPCR) opens a new possibility in drug discovery. Harnessing our knowledge of molecular mechanisms and structural information of GPCRs will be advantageous for developing effective drugs. This review provides an overview of the role of GPCRs in various neurodegenerative and psychiatric diseases. Besides, we highlight the emerging opportunities of novel GPCR targets and address recent progress in GPCR drug development.

AB - Neuropsychiatric disorders are multifactorial disorders with diverse aetiological factors. Identifying treatment targets is challenging because the diseases are resulting from heterogeneous biological, genetic, and environmental factors. Nevertheless, the increasing understanding of G protein-coupled receptor (GPCR) opens a new possibility in drug discovery. Harnessing our knowledge of molecular mechanisms and structural information of GPCRs will be advantageous for developing effective drugs. This review provides an overview of the role of GPCRs in various neurodegenerative and psychiatric diseases. Besides, we highlight the emerging opportunities of novel GPCR targets and address recent progress in GPCR drug development.

UR - https://www.scopus.com/pages/publications/85157972904

U2 - 10.1038/s41392-023-01427-2

DO - 10.1038/s41392-023-01427-2

M3 - 文献综述

C2 - 37137892

AN - SCOPUS:85157972904

SN - 2095-9907

VL - 8

JO - Signal Transduction and Targeted Therapy

JF - Signal Transduction and Targeted Therapy

IS - 1

M1 - 177

ER -

G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders

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