Functionalized nanopipettes for pH-gated single cell DNA delivery

Shi Yu Zheng; Man Sha Wu; Shi Yi Zhang; Meng Qi Zhao; Xin Yue Liu; Bin Bin Chen; Da Wei Li; Ruo Can Qian; Jian Lv

doi:10.1039/d5cc05685c

Functionalized nanopipettes for pH-gated single cell DNA delivery

Shi Yu Zheng
, Man Sha Wu
, Shi Yi Zhang
, Meng Qi Zhao
, Xin Yue Liu
, Bin Bin Chen
, Da Wei Li
, Ruo Can Qian^*
, Jian Lv^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Here, we present i-motif-functionalized glass nanopipettes that enable pH-triggered DNA release into single living cells. Acid-induced folding of the i-motif drives complementary strand dissociation through the ∼80 nm tip with minimal invasiveness. This pH-gated nanopipette enables reversible, on-demand single cell DNA delivery via rectification changes, establishing a potential platform for intracellular manipulation.

Original language	English
Journal	Chemical Communications
DOIs	https://doi.org/10.1039/d5cc05685c
State	Accepted/In press - 2025
Externally published	Yes

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10.1039/d5cc05685c

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title = "Functionalized nanopipettes for pH-gated single cell DNA delivery",

abstract = "Here, we present i-motif-functionalized glass nanopipettes that enable pH-triggered DNA release into single living cells. Acid-induced folding of the i-motif drives complementary strand dissociation through the ∼80 nm tip with minimal invasiveness. This pH-gated nanopipette enables reversible, on-demand single cell DNA delivery via rectification changes, establishing a potential platform for intracellular manipulation.",

author = "Zheng, \{Shi Yu\} and Wu, \{Man Sha\} and Zhang, \{Shi Yi\} and Zhao, \{Meng Qi\} and Liu, \{Xin Yue\} and Chen, \{Bin Bin\} and Li, \{Da Wei\} and Qian, \{Ruo Can\} and Jian Lv",

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year = "2025",

doi = "10.1039/d5cc05685c",

language = "英语",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Functionalized nanopipettes for pH-gated single cell DNA delivery

AU - Zheng, Shi Yu

AU - Wu, Man Sha

AU - Zhang, Shi Yi

AU - Zhao, Meng Qi

AU - Liu, Xin Yue

AU - Chen, Bin Bin

AU - Li, Da Wei

AU - Qian, Ruo Can

AU - Lv, Jian

PY - 2025

Y1 - 2025

N2 - Here, we present i-motif-functionalized glass nanopipettes that enable pH-triggered DNA release into single living cells. Acid-induced folding of the i-motif drives complementary strand dissociation through the ∼80 nm tip with minimal invasiveness. This pH-gated nanopipette enables reversible, on-demand single cell DNA delivery via rectification changes, establishing a potential platform for intracellular manipulation.

AB - Here, we present i-motif-functionalized glass nanopipettes that enable pH-triggered DNA release into single living cells. Acid-induced folding of the i-motif drives complementary strand dissociation through the ∼80 nm tip with minimal invasiveness. This pH-gated nanopipette enables reversible, on-demand single cell DNA delivery via rectification changes, establishing a potential platform for intracellular manipulation.

UR - https://www.scopus.com/pages/publications/105024808239

U2 - 10.1039/d5cc05685c

DO - 10.1039/d5cc05685c

M3 - 文章

AN - SCOPUS:105024808239

SN - 1359-7345

JO - Chemical Communications

JF - Chemical Communications

ER -

Functionalized nanopipettes for pH-gated single cell DNA delivery

Abstract

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