Functionalized Metal-Organic Framework UiO-66-NH-BQB for Selective Detection of Hydrogen Sulfide and Cysteine

Huazheng Yu; Chuanyao Liu; Yanhong Li; Aisheng Huang

doi:10.1021/acsami.9b16529

Functionalized Metal-Organic Framework UiO-66-NH-BQB for Selective Detection of Hydrogen Sulfide and Cysteine

Huazheng Yu
, Chuanyao Liu
, Yanhong Li^*
, Aisheng Huang

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

East China Normal University

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Hydrogen sulfide (H₂S) is an important signaling molecule related to many diseases. Thus, H₂S has a great impact on the pathological and physiological processes in biological systems. Cysteine (l-Cys) is a building block for proteins and important metabolites. To understand their roles in the physiological metabolic procedures, the measurement of the H₂S level and identifying cysteine in the biological system is significant. In this study, through the functionalization of UiO-66-NH₂ by 4-(2,2-dicyanoethenyl)benzoic acid (BQB), a novel UiO-66-NH-BQB is successfully synthesized and used as a fluorescence probe to recognize and detect H₂S and l-Cys. The fluorescence signals of the probe are enhanced great when it is exposed to H₂S or cysteine molecules; thus, it is able to determine quantificationally the H₂S concentration in an aqueous solution. The detection limitation of the UiO-66-NH-BQB to H₂S concentration is found to be as low as 1.74 μM. The developed fluorescent probe based on UiO-66-NH-BQB displays a high selectivity and excellent biocompatibility, which is very promising for recognition and sensing of biothiols in organisms.

Original language	English
Pages (from-to)	41972-41978
Number of pages	7
Journal	ACS Applied Materials and Interfaces
Volume	11
Issue number	45
DOIs	https://doi.org/10.1021/acsami.9b16529
State	Published - 13 Nov 2019

Keywords

biothiols recognition
fluorescent probes
functionalization
metal-organic framework
sensor

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title = "Functionalized Metal-Organic Framework UiO-66-NH-BQB for Selective Detection of Hydrogen Sulfide and Cysteine",

abstract = "Hydrogen sulfide (H2S) is an important signaling molecule related to many diseases. Thus, H2S has a great impact on the pathological and physiological processes in biological systems. Cysteine (l-Cys) is a building block for proteins and important metabolites. To understand their roles in the physiological metabolic procedures, the measurement of the H2S level and identifying cysteine in the biological system is significant. In this study, through the functionalization of UiO-66-NH2 by 4-(2,2-dicyanoethenyl)benzoic acid (BQB), a novel UiO-66-NH-BQB is successfully synthesized and used as a fluorescence probe to recognize and detect H2S and l-Cys. The fluorescence signals of the probe are enhanced great when it is exposed to H2S or cysteine molecules; thus, it is able to determine quantificationally the H2S concentration in an aqueous solution. The detection limitation of the UiO-66-NH-BQB to H2S concentration is found to be as low as 1.74 μM. The developed fluorescent probe based on UiO-66-NH-BQB displays a high selectivity and excellent biocompatibility, which is very promising for recognition and sensing of biothiols in organisms.",

keywords = "biothiols recognition, fluorescent probes, functionalization, metal-organic framework, sensor",

author = "Huazheng Yu and Chuanyao Liu and Yanhong Li and Aisheng Huang",

note = "Publisher Copyright: {\textcopyright} 2019 American Chemical Society.",

year = "2019",

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doi = "10.1021/acsami.9b16529",

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T1 - Functionalized Metal-Organic Framework UiO-66-NH-BQB for Selective Detection of Hydrogen Sulfide and Cysteine

AU - Yu, Huazheng

AU - Liu, Chuanyao

AU - Li, Yanhong

AU - Huang, Aisheng

PY - 2019/11/13

Y1 - 2019/11/13

N2 - Hydrogen sulfide (H2S) is an important signaling molecule related to many diseases. Thus, H2S has a great impact on the pathological and physiological processes in biological systems. Cysteine (l-Cys) is a building block for proteins and important metabolites. To understand their roles in the physiological metabolic procedures, the measurement of the H2S level and identifying cysteine in the biological system is significant. In this study, through the functionalization of UiO-66-NH2 by 4-(2,2-dicyanoethenyl)benzoic acid (BQB), a novel UiO-66-NH-BQB is successfully synthesized and used as a fluorescence probe to recognize and detect H2S and l-Cys. The fluorescence signals of the probe are enhanced great when it is exposed to H2S or cysteine molecules; thus, it is able to determine quantificationally the H2S concentration in an aqueous solution. The detection limitation of the UiO-66-NH-BQB to H2S concentration is found to be as low as 1.74 μM. The developed fluorescent probe based on UiO-66-NH-BQB displays a high selectivity and excellent biocompatibility, which is very promising for recognition and sensing of biothiols in organisms.

AB - Hydrogen sulfide (H2S) is an important signaling molecule related to many diseases. Thus, H2S has a great impact on the pathological and physiological processes in biological systems. Cysteine (l-Cys) is a building block for proteins and important metabolites. To understand their roles in the physiological metabolic procedures, the measurement of the H2S level and identifying cysteine in the biological system is significant. In this study, through the functionalization of UiO-66-NH2 by 4-(2,2-dicyanoethenyl)benzoic acid (BQB), a novel UiO-66-NH-BQB is successfully synthesized and used as a fluorescence probe to recognize and detect H2S and l-Cys. The fluorescence signals of the probe are enhanced great when it is exposed to H2S or cysteine molecules; thus, it is able to determine quantificationally the H2S concentration in an aqueous solution. The detection limitation of the UiO-66-NH-BQB to H2S concentration is found to be as low as 1.74 μM. The developed fluorescent probe based on UiO-66-NH-BQB displays a high selectivity and excellent biocompatibility, which is very promising for recognition and sensing of biothiols in organisms.

KW - biothiols recognition

KW - fluorescent probes

KW - functionalization

KW - metal-organic framework

KW - sensor

UR - https://www.scopus.com/pages/publications/85074765766

U2 - 10.1021/acsami.9b16529

DO - 10.1021/acsami.9b16529

M3 - 文章

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AN - SCOPUS:85074765766

SN - 1944-8244

VL - 11

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EP - 41978

JO - ACS Applied Materials and Interfaces

JF - ACS Applied Materials and Interfaces

IS - 45

ER -

Functionalized Metal-Organic Framework UiO-66-NH-BQB for Selective Detection of Hydrogen Sulfide and Cysteine

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Keywords

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