Functional conversion of nickel-containing metalloproteins via molecular design: From a truncated acetyl-coenzyme A synthase to a nickel superoxide dismutase

Yi Liu; Qingli Wang; Yaozhu Wei; Ying Wu Lin; Wei Li; Ji Hu Su; Zhen Wang; Yang Tian; Zhong Xian Huang; Xiangshi Tan

doi:10.1039/c2cc38224e

Functional conversion of nickel-containing metalloproteins via molecular design: From a truncated acetyl-coenzyme A synthase to a nickel superoxide dismutase

Yi Liu
, Qingli Wang
, Yaozhu Wei
, Ying Wu Lin
, Wei Li
, Ji Hu Su
, Zhen Wang
, Yang Tian
, Zhong Xian Huang
, Xiangshi Tan^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Truncated acetyl-coenzyme A synthase (ACS) was successfully converted into functional nickel superoxide dismutase (Ni-SOD) by molecular design and the designed metalloproteins possess new spectroscopic, structural, and electrochemical characteristics required for catalyzing O₂?⁻ disproportionation, and exhibit impressive Ni-SOD activity.

Original language	English
Pages (from-to)	1452-1454
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	14
DOIs	https://doi.org/10.1039/c2cc38224e
State	Published - 22 Jan 2013
Externally published	Yes

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title = "Functional conversion of nickel-containing metalloproteins via molecular design: From a truncated acetyl-coenzyme A synthase to a nickel superoxide dismutase",

abstract = "Truncated acetyl-coenzyme A synthase (ACS) was successfully converted into functional nickel superoxide dismutase (Ni-SOD) by molecular design and the designed metalloproteins possess new spectroscopic, structural, and electrochemical characteristics required for catalyzing O2?− disproportionation, and exhibit impressive Ni-SOD activity.",

author = "Yi Liu and Qingli Wang and Yaozhu Wei and Lin, \{Ying Wu\} and Wei Li and Su, \{Ji Hu\} and Zhen Wang and Yang Tian and Huang, \{Zhong Xian\} and Xiangshi Tan",

year = "2013",

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doi = "10.1039/c2cc38224e",

language = "英语",

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TY - JOUR

T1 - Functional conversion of nickel-containing metalloproteins via molecular design

T2 - From a truncated acetyl-coenzyme A synthase to a nickel superoxide dismutase

AU - Liu, Yi

AU - Wang, Qingli

AU - Wei, Yaozhu

AU - Lin, Ying Wu

AU - Li, Wei

AU - Su, Ji Hu

AU - Wang, Zhen

AU - Tian, Yang

AU - Huang, Zhong Xian

AU - Tan, Xiangshi

PY - 2013/1/22

Y1 - 2013/1/22

N2 - Truncated acetyl-coenzyme A synthase (ACS) was successfully converted into functional nickel superoxide dismutase (Ni-SOD) by molecular design and the designed metalloproteins possess new spectroscopic, structural, and electrochemical characteristics required for catalyzing O2?− disproportionation, and exhibit impressive Ni-SOD activity.

AB - Truncated acetyl-coenzyme A synthase (ACS) was successfully converted into functional nickel superoxide dismutase (Ni-SOD) by molecular design and the designed metalloproteins possess new spectroscopic, structural, and electrochemical characteristics required for catalyzing O2?− disproportionation, and exhibit impressive Ni-SOD activity.

UR - https://www.scopus.com/pages/publications/84872703148

U2 - 10.1039/c2cc38224e

DO - 10.1039/c2cc38224e

M3 - 文章

C2 - 23322089

AN - SCOPUS:84872703148

SN - 1359-7345

VL - 49

SP - 1452

EP - 1454

JO - Chemical Communications

JF - Chemical Communications

IS - 14

ER -

Functional conversion of nickel-containing metalloproteins via molecular design: From a truncated acetyl-coenzyme A synthase to a nickel superoxide dismutase

Abstract

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