Fluorescent chemodosimeter for Cys/Hcy with a large absorption shift and imaging in living cells

Mingming Hu; Jiangli Fan; Honglin Li; Kedong Song; Song Wang; Guanghui Cheng; Xiaojun Peng

doi:10.1039/c0ob00957a

Fluorescent chemodosimeter for Cys/Hcy with a large absorption shift and imaging in living cells

Mingming Hu
, Jiangli Fan^*
, Honglin Li
, Kedong Song
, Song Wang
, Guanghui Cheng
, Xiaojun Peng

^*Corresponding author for this work

Dalian University of Technology

Research output: Contribution to journal › Article › peer-review

126 Scopus citations

Abstract

A novel molecule T1 with efficient intramolecular charge transfer was designed as a fluorescent chemodosimeter for cysteine (Cys) and homocysteine (Hcy). Upon addition of Cys/Hcy, T1 exhibited greatly enhanced fluorescence intensity as well as a large absorption peak shift (70 nm), and can be used for bioimaging of Cys/Hcy in living cells and detection in human plasma by visual color change. The detection mechanism was proved by ¹H NMR, mass spectrometry analysis and Gaussian calculations.

Original language	English
Pages (from-to)	980-983
Number of pages	4
Journal	Organic and Biomolecular Chemistry
Volume	9
Issue number	4
DOIs	https://doi.org/10.1039/c0ob00957a
State	Published - 21 Feb 2011
Externally published	Yes

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abstract = "A novel molecule T1 with efficient intramolecular charge transfer was designed as a fluorescent chemodosimeter for cysteine (Cys) and homocysteine (Hcy). Upon addition of Cys/Hcy, T1 exhibited greatly enhanced fluorescence intensity as well as a large absorption peak shift (70 nm), and can be used for bioimaging of Cys/Hcy in living cells and detection in human plasma by visual color change. The detection mechanism was proved by 1H NMR, mass spectrometry analysis and Gaussian calculations.",

author = "Mingming Hu and Jiangli Fan and Honglin Li and Kedong Song and Song Wang and Guanghui Cheng and Xiaojun Peng",

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T1 - Fluorescent chemodosimeter for Cys/Hcy with a large absorption shift and imaging in living cells

AU - Hu, Mingming

AU - Fan, Jiangli

AU - Li, Honglin

AU - Song, Kedong

AU - Wang, Song

AU - Cheng, Guanghui

AU - Peng, Xiaojun

PY - 2011/2/21

Y1 - 2011/2/21

N2 - A novel molecule T1 with efficient intramolecular charge transfer was designed as a fluorescent chemodosimeter for cysteine (Cys) and homocysteine (Hcy). Upon addition of Cys/Hcy, T1 exhibited greatly enhanced fluorescence intensity as well as a large absorption peak shift (70 nm), and can be used for bioimaging of Cys/Hcy in living cells and detection in human plasma by visual color change. The detection mechanism was proved by 1H NMR, mass spectrometry analysis and Gaussian calculations.

AB - A novel molecule T1 with efficient intramolecular charge transfer was designed as a fluorescent chemodosimeter for cysteine (Cys) and homocysteine (Hcy). Upon addition of Cys/Hcy, T1 exhibited greatly enhanced fluorescence intensity as well as a large absorption peak shift (70 nm), and can be used for bioimaging of Cys/Hcy in living cells and detection in human plasma by visual color change. The detection mechanism was proved by 1H NMR, mass spectrometry analysis and Gaussian calculations.

UR - https://www.scopus.com/pages/publications/79551655318

U2 - 10.1039/c0ob00957a

DO - 10.1039/c0ob00957a

M3 - 文章

C2 - 21165468

AN - SCOPUS:79551655318

SN - 1477-0520

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EP - 983

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 4

ER -

Fluorescent chemodosimeter for Cys/Hcy with a large absorption shift and imaging in living cells

Abstract

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