Fluorescence imaging of a potential diagnostic biomarker for breast cancer cells using a peptide-functionalized fluorogenic 2D material

Wei Tao Dou; Li Fang Liu; Jie Gao; Yi Zang; Guo Rong Chen; Robert A. Field; Tony D. James; Jia Li; Xiao Peng He

doi:10.1039/c9cc06399d

Fluorescence imaging of a potential diagnostic biomarker for breast cancer cells using a peptide-functionalized fluorogenic 2D material

Wei Tao Dou
, Li Fang Liu
, Jie Gao
, Yi Zang^*
, Guo Rong Chen
, Robert A. Field
, Tony D. James
, Jia Li
, Xiao Peng He

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Protein C receptor (PROCR) is a recently discovered transmembrane biomarker for several tissue stem cells and is highly expressed in triple-negative breast cancer (TNBC) patient-derived xenografts. Herein, to enrich the toolbox for the biochemical evaluation of PROCR, we have developed a peptide-functionalized fluorogenic 2D material based on the self-assembly between a fluorescent peptide probe and thin-layer molybdenum disulfide. The material developed was suitable for the sensitive detection of PROCR recombinant protein in buffer solution and the fluorescence imaging of TNBC cells that express high levels of PROCR.

Original language	English
Pages (from-to)	13235-13238
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	88
DOIs	https://doi.org/10.1039/c9cc06399d
State	Published - 2019
Externally published	Yes

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10.1039/c9cc06399d

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@article{14586314cc684ef68acfa966648bd1a8,

title = "Fluorescence imaging of a potential diagnostic biomarker for breast cancer cells using a peptide-functionalized fluorogenic 2D material",

abstract = "Protein C receptor (PROCR) is a recently discovered transmembrane biomarker for several tissue stem cells and is highly expressed in triple-negative breast cancer (TNBC) patient-derived xenografts. Herein, to enrich the toolbox for the biochemical evaluation of PROCR, we have developed a peptide-functionalized fluorogenic 2D material based on the self-assembly between a fluorescent peptide probe and thin-layer molybdenum disulfide. The material developed was suitable for the sensitive detection of PROCR recombinant protein in buffer solution and the fluorescence imaging of TNBC cells that express high levels of PROCR.",

author = "Dou, \{Wei Tao\} and Liu, \{Li Fang\} and Jie Gao and Yi Zang and Chen, \{Guo Rong\} and Field, \{Robert A.\} and James, \{Tony D.\} and Jia Li and He, \{Xiao Peng\}",

note = "Publisher Copyright: This journal is {\textcopyright} The Royal Society of Chemistry.",

year = "2019",

doi = "10.1039/c9cc06399d",

language = "英语",

volume = "55",

pages = "13235--13238",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

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}

TY - JOUR

T1 - Fluorescence imaging of a potential diagnostic biomarker for breast cancer cells using a peptide-functionalized fluorogenic 2D material

AU - Dou, Wei Tao

AU - Liu, Li Fang

AU - Gao, Jie

AU - Zang, Yi

AU - Chen, Guo Rong

AU - Field, Robert A.

AU - James, Tony D.

AU - Li, Jia

AU - He, Xiao Peng

PY - 2019

Y1 - 2019

N2 - Protein C receptor (PROCR) is a recently discovered transmembrane biomarker for several tissue stem cells and is highly expressed in triple-negative breast cancer (TNBC) patient-derived xenografts. Herein, to enrich the toolbox for the biochemical evaluation of PROCR, we have developed a peptide-functionalized fluorogenic 2D material based on the self-assembly between a fluorescent peptide probe and thin-layer molybdenum disulfide. The material developed was suitable for the sensitive detection of PROCR recombinant protein in buffer solution and the fluorescence imaging of TNBC cells that express high levels of PROCR.

AB - Protein C receptor (PROCR) is a recently discovered transmembrane biomarker for several tissue stem cells and is highly expressed in triple-negative breast cancer (TNBC) patient-derived xenografts. Herein, to enrich the toolbox for the biochemical evaluation of PROCR, we have developed a peptide-functionalized fluorogenic 2D material based on the self-assembly between a fluorescent peptide probe and thin-layer molybdenum disulfide. The material developed was suitable for the sensitive detection of PROCR recombinant protein in buffer solution and the fluorescence imaging of TNBC cells that express high levels of PROCR.

UR - https://www.scopus.com/pages/publications/85074308140

U2 - 10.1039/c9cc06399d

DO - 10.1039/c9cc06399d

M3 - 文章

C2 - 31621698

AN - SCOPUS:85074308140

SN - 1359-7345

VL - 55

SP - 13235

EP - 13238

JO - Chemical Communications

JF - Chemical Communications

IS - 88

ER -

Fluorescence imaging of a potential diagnostic biomarker for breast cancer cells using a peptide-functionalized fluorogenic 2D material

Abstract

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