Flow-injection chemiluminescence determination of meloxicam by oxidation with N-bromosuccinimide

Haiyan Liu; Ling Zhang; Yuhong Hao; Qingjiang Wang; Pingang He; Yuzhi Fang

doi:10.1016/j.aca.2005.02.078

Flow-injection chemiluminescence determination of meloxicam by oxidation with N-bromosuccinimide

Haiyan Liu
, Ling Zhang
, Yuhong Hao
, Qingjiang Wang
, Pingang He^*
, Yuzhi Fang

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

A rapid and sensitive flow-injection chemiluminescence method is described for the determination of meloxicam based on its reaction with N-bromosuccinimide (NBS) in alkaline medium. Under the optimum conditions, the proposed method allows the measurement of meloxicam over the range of 2.2 × 10 ^-7 to 2.8 × 10^-5 mol/l with a detection limit of 7.7 × 10^-8 mol/l. The relative standard deviation for 11 parallel measurements of 2.8 × 10^-6 mol/l meloxicam is 2.14%. The method has been applied satisfactorily to the determination of meloxicam in pharmaceutical preparations. The results agree well with those obtained by spectrophotometry. The mechanism of the chemiluminescence reaction is briefly explained with spectroscopic evidence.

Original language	English
Pages (from-to)	185-190
Number of pages	6
Journal	Analytica Chimica Acta
Volume	541
Issue number	1-2
DOIs	https://doi.org/10.1016/j.aca.2005.02.078
State	Published - 13 Jun 2005

Keywords

Chemiluminescence
Flow-injection
Meloxicam
N-Bromosuccinimide

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10.1016/j.aca.2005.02.078

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title = "Flow-injection chemiluminescence determination of meloxicam by oxidation with N-bromosuccinimide",

abstract = "A rapid and sensitive flow-injection chemiluminescence method is described for the determination of meloxicam based on its reaction with N-bromosuccinimide (NBS) in alkaline medium. Under the optimum conditions, the proposed method allows the measurement of meloxicam over the range of 2.2 × 10 -7 to 2.8 × 10-5 mol/l with a detection limit of 7.7 × 10-8 mol/l. The relative standard deviation for 11 parallel measurements of 2.8 × 10-6 mol/l meloxicam is 2.14\%. The method has been applied satisfactorily to the determination of meloxicam in pharmaceutical preparations. The results agree well with those obtained by spectrophotometry. The mechanism of the chemiluminescence reaction is briefly explained with spectroscopic evidence.",

keywords = "Chemiluminescence, Flow-injection, Meloxicam, N-Bromosuccinimide",

author = "Haiyan Liu and Ling Zhang and Yuhong Hao and Qingjiang Wang and Pingang He and Yuzhi Fang",

year = "2005",

month = jun,

day = "13",

doi = "10.1016/j.aca.2005.02.078",

language = "英语",

volume = "541",

pages = "185--190",

journal = "Analytica Chimica Acta",

issn = "0003-2670",

publisher = "Elsevier B.V.",

number = "1-2",

}

TY - JOUR

T1 - Flow-injection chemiluminescence determination of meloxicam by oxidation with N-bromosuccinimide

AU - Liu, Haiyan

AU - Zhang, Ling

AU - Hao, Yuhong

AU - Wang, Qingjiang

AU - He, Pingang

AU - Fang, Yuzhi

PY - 2005/6/13

Y1 - 2005/6/13

N2 - A rapid and sensitive flow-injection chemiluminescence method is described for the determination of meloxicam based on its reaction with N-bromosuccinimide (NBS) in alkaline medium. Under the optimum conditions, the proposed method allows the measurement of meloxicam over the range of 2.2 × 10 -7 to 2.8 × 10-5 mol/l with a detection limit of 7.7 × 10-8 mol/l. The relative standard deviation for 11 parallel measurements of 2.8 × 10-6 mol/l meloxicam is 2.14%. The method has been applied satisfactorily to the determination of meloxicam in pharmaceutical preparations. The results agree well with those obtained by spectrophotometry. The mechanism of the chemiluminescence reaction is briefly explained with spectroscopic evidence.

AB - A rapid and sensitive flow-injection chemiluminescence method is described for the determination of meloxicam based on its reaction with N-bromosuccinimide (NBS) in alkaline medium. Under the optimum conditions, the proposed method allows the measurement of meloxicam over the range of 2.2 × 10 -7 to 2.8 × 10-5 mol/l with a detection limit of 7.7 × 10-8 mol/l. The relative standard deviation for 11 parallel measurements of 2.8 × 10-6 mol/l meloxicam is 2.14%. The method has been applied satisfactorily to the determination of meloxicam in pharmaceutical preparations. The results agree well with those obtained by spectrophotometry. The mechanism of the chemiluminescence reaction is briefly explained with spectroscopic evidence.

KW - Chemiluminescence

KW - Flow-injection

KW - Meloxicam

KW - N-Bromosuccinimide

UR - https://www.scopus.com/pages/publications/19944374092

U2 - 10.1016/j.aca.2005.02.078

DO - 10.1016/j.aca.2005.02.078

M3 - 文章

AN - SCOPUS:19944374092

SN - 0003-2670

VL - 541

SP - 185

EP - 190

JO - Analytica Chimica Acta

JF - Analytica Chimica Acta

IS - 1-2

ER -

Flow-injection chemiluminescence determination of meloxicam by oxidation with N-bromosuccinimide

Abstract

Keywords

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