Five-member thio-heterocyclic fused naphthalimides with aminoalkyl side chains: Intercalation and photocleavage to DNA

Yufang Xu; Baoyuan Qu; Xuhong Qian; Yonggang Li

doi:10.1016/j.bmcl.2004.12.011

Five-member thio-heterocyclic fused naphthalimides with aminoalkyl side chains: Intercalation and photocleavage to DNA

Yufang Xu
, Baoyuan Qu
, Xuhong Qian^*
, Yonggang Li

^*Corresponding author for this work

East China University of Science and Technology
Dalian University of Technology

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Novel five-member thio-heterocyclic fused naphthalimides with aminoalkyl side chains were designed, synthesized and evaluated. These compounds have high Scatchard binding constants. They could damage DNA (supercoiled pBR322) from form I (closed) to II (nicked) at a concentration as low as 10 μM and from form I to form III at a concentration of 50 μM. The results implied that the influence of intercalating ability of chromophores on photocleaving ability of photocleavers depended on the mechanism of photocleavage.

Original language	English
Pages (from-to)	1139-1142
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	15
Issue number	4
DOIs	https://doi.org/10.1016/j.bmcl.2004.12.011
State	Published - 15 Feb 2005
Externally published	Yes

Keywords

Five-member
Intercalation
Photocleavage
Thio-heterocyclic fused naphthalimide

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10.1016/j.bmcl.2004.12.011

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title = "Five-member thio-heterocyclic fused naphthalimides with aminoalkyl side chains: Intercalation and photocleavage to DNA",

abstract = "Novel five-member thio-heterocyclic fused naphthalimides with aminoalkyl side chains were designed, synthesized and evaluated. These compounds have high Scatchard binding constants. They could damage DNA (supercoiled pBR322) from form I (closed) to II (nicked) at a concentration as low as 10 μM and from form I to form III at a concentration of 50 μM. The results implied that the influence of intercalating ability of chromophores on photocleaving ability of photocleavers depended on the mechanism of photocleavage.",

keywords = "Five-member, Intercalation, Photocleavage, Thio-heterocyclic fused naphthalimide",

author = "Yufang Xu and Baoyuan Qu and Xuhong Qian and Yonggang Li",

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T1 - Five-member thio-heterocyclic fused naphthalimides with aminoalkyl side chains

T2 - Intercalation and photocleavage to DNA

AU - Xu, Yufang

AU - Qu, Baoyuan

AU - Qian, Xuhong

AU - Li, Yonggang

PY - 2005/2/15

Y1 - 2005/2/15

N2 - Novel five-member thio-heterocyclic fused naphthalimides with aminoalkyl side chains were designed, synthesized and evaluated. These compounds have high Scatchard binding constants. They could damage DNA (supercoiled pBR322) from form I (closed) to II (nicked) at a concentration as low as 10 μM and from form I to form III at a concentration of 50 μM. The results implied that the influence of intercalating ability of chromophores on photocleaving ability of photocleavers depended on the mechanism of photocleavage.

AB - Novel five-member thio-heterocyclic fused naphthalimides with aminoalkyl side chains were designed, synthesized and evaluated. These compounds have high Scatchard binding constants. They could damage DNA (supercoiled pBR322) from form I (closed) to II (nicked) at a concentration as low as 10 μM and from form I to form III at a concentration of 50 μM. The results implied that the influence of intercalating ability of chromophores on photocleaving ability of photocleavers depended on the mechanism of photocleavage.

KW - Five-member

KW - Intercalation

KW - Photocleavage

KW - Thio-heterocyclic fused naphthalimide

UR - https://www.scopus.com/pages/publications/16244392102

U2 - 10.1016/j.bmcl.2004.12.011

DO - 10.1016/j.bmcl.2004.12.011

M3 - 文章

C2 - 15686929

AN - SCOPUS:16244392102

SN - 0960-894X

VL - 15

SP - 1139

EP - 1142

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 4

ER -

Five-member thio-heterocyclic fused naphthalimides with aminoalkyl side chains: Intercalation and photocleavage to DNA

Abstract

Keywords

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