Fibrinolytic compounds isolated from a brown alga, Sargassum fulvellum

Wenhui Wu; Keiji Hasumi; Hui Peng; Xianwen Hu; Xichang Wang; Bin Bao

doi:10.3390/md7020085

Fibrinolytic compounds isolated from a brown alga, Sargassum fulvellum

Wenhui Wu
, Keiji Hasumi
, Hui Peng
, Xianwen Hu
, Xichang Wang
, Bin Bao^*

^*Corresponding author for this work

Shanghai Ocean University
Tokyo University of Agriculture and Technology
The University of Auckland
Institute of Biotechnology

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Two of bioactive natural products were founded in a brown alga, Sargassum fulvellum. After isolation and purification, the molecular structures of these two products were investigated by NMR spectroscopy and GC-mass spectroscopy. The two compounds were identified to be 1-O-palmitoyl-2-O-oleoyl-3-O-(α-D- glucopyranosyl) -glycerol (POGG) and 1-O-myristoyl-2-O-oleoyl-3-O-(α-D- glucopyranosyl) - glycerol (MOGG) which were obtained from Sargassum fulvellum for the first time. POGG and MOGG showed fibrinolytic activity in the reaction system of pro-u-PA and plasminogen.

Original language	English
Pages (from-to)	85-94
Number of pages	10
Journal	Marine Drugs
Volume	7
Issue number	2
DOIs	https://doi.org/10.3390/md7020085
State	Published - Jun 2009
Externally published	Yes

Keywords

Fibrinolytic activity
Glucopyranosyldiacylglycerol
NMR
Sargassum fulvellum
Structure determination

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10.3390/md7020085

Cite this

@article{4e5b095e520a4bd6a12e5ddb173be5a1,

title = "Fibrinolytic compounds isolated from a brown alga, Sargassum fulvellum",

abstract = "Two of bioactive natural products were founded in a brown alga, Sargassum fulvellum. After isolation and purification, the molecular structures of these two products were investigated by NMR spectroscopy and GC-mass spectroscopy. The two compounds were identified to be 1-O-palmitoyl-2-O-oleoyl-3-O-(α-D- glucopyranosyl) -glycerol (POGG) and 1-O-myristoyl-2-O-oleoyl-3-O-(α-D- glucopyranosyl) - glycerol (MOGG) which were obtained from Sargassum fulvellum for the first time. POGG and MOGG showed fibrinolytic activity in the reaction system of pro-u-PA and plasminogen.",

keywords = "Fibrinolytic activity, Glucopyranosyldiacylglycerol, NMR, Sargassum fulvellum, Structure determination",

author = "Wenhui Wu and Keiji Hasumi and Hui Peng and Xianwen Hu and Xichang Wang and Bin Bao",

year = "2009",

month = jun,

doi = "10.3390/md7020085",

language = "英语",

volume = "7",

pages = "85--94",

journal = "Marine Drugs",

issn = "1660-3397",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "2",

}

TY - JOUR

T1 - Fibrinolytic compounds isolated from a brown alga, Sargassum fulvellum

AU - Wu, Wenhui

AU - Hasumi, Keiji

AU - Peng, Hui

AU - Hu, Xianwen

AU - Wang, Xichang

AU - Bao, Bin

PY - 2009/6

Y1 - 2009/6

N2 - Two of bioactive natural products were founded in a brown alga, Sargassum fulvellum. After isolation and purification, the molecular structures of these two products were investigated by NMR spectroscopy and GC-mass spectroscopy. The two compounds were identified to be 1-O-palmitoyl-2-O-oleoyl-3-O-(α-D- glucopyranosyl) -glycerol (POGG) and 1-O-myristoyl-2-O-oleoyl-3-O-(α-D- glucopyranosyl) - glycerol (MOGG) which were obtained from Sargassum fulvellum for the first time. POGG and MOGG showed fibrinolytic activity in the reaction system of pro-u-PA and plasminogen.

AB - Two of bioactive natural products were founded in a brown alga, Sargassum fulvellum. After isolation and purification, the molecular structures of these two products were investigated by NMR spectroscopy and GC-mass spectroscopy. The two compounds were identified to be 1-O-palmitoyl-2-O-oleoyl-3-O-(α-D- glucopyranosyl) -glycerol (POGG) and 1-O-myristoyl-2-O-oleoyl-3-O-(α-D- glucopyranosyl) - glycerol (MOGG) which were obtained from Sargassum fulvellum for the first time. POGG and MOGG showed fibrinolytic activity in the reaction system of pro-u-PA and plasminogen.

KW - Fibrinolytic activity

KW - Glucopyranosyldiacylglycerol

KW - NMR

KW - Sargassum fulvellum

KW - Structure determination

UR - https://www.scopus.com/pages/publications/66449134801

U2 - 10.3390/md7020085

DO - 10.3390/md7020085

M3 - 文章

C2 - 19597573

AN - SCOPUS:66449134801

SN - 1660-3397

VL - 7

SP - 85

EP - 94

JO - Marine Drugs

JF - Marine Drugs

IS - 2

ER -

Fibrinolytic compounds isolated from a brown alga, Sargassum fulvellum

Abstract

Keywords

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