Far-red imaging of β-galactosidase through a phospha-fluorescein

Zichao Ding; Chuanfeng Wang; Mengting Fan; Mengyuan Zhang; Yao Zhou; Xiaoyan Cui; Dazhi Zhang; Ting Wang

doi:10.1039/d0cc05529h

Far-red imaging of β-galactosidase through a phospha-fluorescein

Zichao Ding
, Chuanfeng Wang
, Mengting Fan
, Mengyuan Zhang
, Yao Zhou
, Xiaoyan Cui
, Dazhi Zhang^*
, Ting Wang

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

Naval Medical University
East China Normal University

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The introduction of phosphine oxide into a fluorescein scaffold has yielded phospha-fluorescein with bathochromically shifted spectra, reliable photostability and solubility. Moreover, ratiometric and turn-on fluorescence in the decaging process has ensured that the phospha-fluorescein is a unique scaffold for fluorescence bioimaging. Probe DiMe-PF-Gal without further structural decoration was designed for accurately monitoring β-galactosidase in vivo.

Original language	English
Pages (from-to)	13579-13582
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	88
DOIs	https://doi.org/10.1039/d0cc05529h
State	Published - 14 Nov 2020

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title = "Far-red imaging of β-galactosidase through a phospha-fluorescein",

abstract = "The introduction of phosphine oxide into a fluorescein scaffold has yielded phospha-fluorescein with bathochromically shifted spectra, reliable photostability and solubility. Moreover, ratiometric and turn-on fluorescence in the decaging process has ensured that the phospha-fluorescein is a unique scaffold for fluorescence bioimaging. Probe DiMe-PF-Gal without further structural decoration was designed for accurately monitoring β-galactosidase in vivo.",

author = "Zichao Ding and Chuanfeng Wang and Mengting Fan and Mengyuan Zhang and Yao Zhou and Xiaoyan Cui and Dazhi Zhang and Ting Wang",

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T1 - Far-red imaging of β-galactosidase through a phospha-fluorescein

AU - Ding, Zichao

AU - Wang, Chuanfeng

AU - Fan, Mengting

AU - Zhang, Mengyuan

AU - Zhou, Yao

AU - Cui, Xiaoyan

AU - Zhang, Dazhi

AU - Wang, Ting

PY - 2020/11/14

Y1 - 2020/11/14

N2 - The introduction of phosphine oxide into a fluorescein scaffold has yielded phospha-fluorescein with bathochromically shifted spectra, reliable photostability and solubility. Moreover, ratiometric and turn-on fluorescence in the decaging process has ensured that the phospha-fluorescein is a unique scaffold for fluorescence bioimaging. Probe DiMe-PF-Gal without further structural decoration was designed for accurately monitoring β-galactosidase in vivo.

AB - The introduction of phosphine oxide into a fluorescein scaffold has yielded phospha-fluorescein with bathochromically shifted spectra, reliable photostability and solubility. Moreover, ratiometric and turn-on fluorescence in the decaging process has ensured that the phospha-fluorescein is a unique scaffold for fluorescence bioimaging. Probe DiMe-PF-Gal without further structural decoration was designed for accurately monitoring β-galactosidase in vivo.

UR - https://www.scopus.com/pages/publications/85095858996

U2 - 10.1039/d0cc05529h

DO - 10.1039/d0cc05529h

M3 - 文章

C2 - 33052367

AN - SCOPUS:85095858996

SN - 1359-7345

VL - 56

SP - 13579

EP - 13582

JO - Chemical Communications

JF - Chemical Communications

IS - 88

ER -

Far-red imaging of β-galactosidase through a phospha-fluorescein

Abstract

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